Application of bromoacetate-substituted β-CD-bonded silica particles as chiral stationary phase for HPLC

被引：16

作者：

Chelvi, Sennappan K. Thamarai ^{[1
]}

Yong, E. L. ^{[1
]}

Gong, Yinhan ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Dept Obstet & Gynaecol, Yong Loo Lin Sch Med, Singapore 119074, Singapore

[2] Natl Univ Singapore, Trop Marine Sci Inst, Singapore 119074, Singapore

来源：

JOURNAL OF SEPARATION SCIENCE | 2010年 / 33卷 / 01期

关键词：

beta-CD; Chiral separation; Chiral stationary phase; HPLC; Macrocycle; PERFORMANCE LIQUID-CHROMATOGRAPHY; CAPILLARY ELECTROCHROMATOGRAPHY; CYCLODEXTRIN; SEPARATION; ISOMERS; ETHER;

D O I：

10.1002/jssc.200900512

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Bromoacetate-substituted [3-(2-O-beta-cyclodextrin)-2-hydroxypropoxy]propylsilyl-appended silica particles (BACD-HPS), an important and useful synthetic intermediate for preparation of novel types of macrocycles-capped beta-CD-bonded silica particles including crown ether/cyclam/calix[4]arene-capped beta-CD-bonded silica particles, have been prepared and used as chiral stationary phase for HPLC. This synthetic stationary phase is characterized by means of elemental analysis. For the first time, the chromatographic behavior of BACD-HPS was systematically evaluated with several disubstituted benzenes and some chiral drug compounds under both normal and RP conditions in HPLC. The results show that BACD-HPS has excellent selectivity for the separation of aromatic positional isomers and chiral isomers of some drug compounds when used as stationary phase in HPLC.

引用

页码：74 / 78

页数：5

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