Synthesis and characterization of poly(ethylene glycol) based β-cyclodextrin polymers

被引：27
|
作者：
Nielsen, Thorbjorn Terndrup [3 ]
Wintgens, Veronique [1 ,2 ]
Larsen, Kim Lambertsen [3 ]
Amiel, Catherine [1 ,2 ]
机构：
[1] CNRS, ICMPE, F-94320 Thiais, France
[2] Univ Paris Est, F-94320 Thiais, France
[3] Aalborg Univ, Dept Biotechnol Chem & Environm Engn, Sect Chem, DK-9000 Aalborg, Denmark
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2009年 / 65卷 / 3-4期
关键词：
Cyclodextrin polymer; Poly(ethylene glycol) copolymer; Inclusion complex; ITC; HYDROGELS; VECTORS;
D O I：
10.1007/s10847-009-9591-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel water soluble beta-cyclodextrin (beta CD) polymers has been synthesized from functionalized poly(ethylene glycol) (PEG). The chemical composition of the polymers has been characterized by H-1 NMR and the beta CD content is found to be between 48 and 33% (w/w). The molecular weight has been determined by Size Exclusion Chromatography (SEC) and depends on the ratio between beta CD and PEG, varying from 2.1 x 10(4) to 8.6 x 10(4) g mol(-1). The physico chemical properties have been characterized by differential scanning calorimetry (DSC), viscometry and isothermal titration calorimetry (ITC). ITC shows that the polymers have association constants comparable to beta CD with different guest molecules, indicating a good accessibility of the CDs.
引用
收藏
页码：341 / 348
页数：8
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