Effects of methyllycaconitine and related analogues on bovine adrenal α3β4*nicotinic acetylcholine receptors

被引：12
作者：
Bryant, DL
Free, RB
Thomasy, SM
Lapinsky, DJ
Ismail, KA
Arason, KM
Bergmeier, SC
McKay, DB
机构：
[1] Ohio State Univ, Div Pharmacol, Coll Pharm, Columbus, OH 43210 USA
[2] Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA
来源：
CHROMAFFIN CELL: TRNSMITTER BIOSYNTHESIS, STORAGE, RELEASE, ACTIONS, AND INFORMATICS | 2002年 / 971卷
关键词：
methyllycaconitine; adrenal alpha 3 beta 4 nicotinic acetylcholine receptors; MLA;
D O I：
10.1111/j.1749-6632.2002.tb04448.x
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal alpha3beta4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.
引用
收藏
页码：139 / 141
页数：3
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