Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation

被引：55

作者：

Cohen, D. J. ^{[1
]}

Cheng, A. ^{[2
,3
,4
]}

Kahn, A. ^{[5
]}

Aviram, M. ^{[6
]}

Whitehead, A. J. ^{[1
]}

Hyzy, S. L. ^{[1
]}

Clohessy, R. M. ^{[1
]}

Boyan, B. D. ^{[1
,2
,3
]}

Schwartz, Z. ^{[1
,7
]}

机构：

[1] Virginia Commonwealth Univ, Dept Biomed Engn, Richmond, VA USA

[2] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA

[3] Emory Univ, Atlanta, GA 30322 USA

[4] Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R China

[5] Tel Aviv Univ, Dept Oral & Maxillofacial Surg, IL-69978 Tel Aviv, Israel

[6] Tipul Behiuch Private Clin, Tel Aviv, Israel

[7] Univ Texas Hlth Sci Ctr San Antonio, Dept Periodont, San Antonio, TX 78229 USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

DIFFERENTIAL RESPONSE; SURFACE-ROUGHNESS; COMPLETE DENTURES; TITANIUM; IMPLANTS; REGENERATION; ALLOY; DEMINERALIZATION; NANOSTRUCTURES; STERILIZATION;

D O I：

10.1038/srep20493

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabrication osteogenic micro-/nano-scale surface texture modification. Human osteoblasts produced osteogenic and angiogenic factors when grown on laser-sintered nano-/micro-textured surfaces compared to smooth surfaces. Surface-processed constructs caused higher bone-to-implant contact, vertical bone growth into disk pores (microCT and histomorphometry), and mechanical pull-out force at 5 and 10 w on rat calvaria compared to non surface-modified constructs, even when pre-treating the bone to stimulate osteogenesis. Surface-modified wrap-implants placed around rabbit tibias osseointegrated by 6 w. Finally, patient-specific constructs designed to support dental implants produced via AM and surface-processing were implanted on edentulous mandibular bone. 3 and 8 month post-operative images showed new bone formation and osseointegration of the device and indicated stability of the dental implants.

引用

页数：12

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