Fat on the move: intracellular motion of lipid droplets

被引：99
|
作者：
Welte, Michael A. [1 ]
机构：
[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2009年 / 37卷
基金：
美国国家卫生研究院;
关键词：
dynein; lipid droplet; microtubule; motility; perilipin/adipose differentiation-related protein (ADRP)/47 kDa tail-interacting protein (TIP47) protein (PAT protein); FUNCTIONAL GENOMIC SCREEN; OOPLASMIC SEGREGATION; DROSOPHILA EMBRYOS; VESICLE TRANSPORT; ENDOPLASMIC-RETICULUM; ORGANELLE TRANSPORT; MOLECULAR MOTORS; ORYZIAS-LATIPES; CARGO TRANSPORT; IN-VIVO;
D O I：
10.1042/BST0370991
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid droplets are intracellular organelles that play central roles in lipid metabolism. in many cells, lipid droplets undergo active motion, typically along microtubules. This motion has been proposed to aid growth and breakdown of droplets, to allow net transfer of nutrients from sites of synthesis to sites of need and to deliver proteins and lipophilic signals. This review summarizes the current understanding of where, why and how lipid droplets move.
引用
收藏
页码：991 / 996
页数：6
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