Recent Synthetic Studies Leading to Structural Revisions of Marine Natural Products

被引：46
作者：
Usami, Yoshihide [1 ]
机构：
[1] Osaka Univ Pharmaceut Sci, Osaka 5691094, Japan
来源：
MARINE DRUGS | 2009年 / 7卷 / 03期
关键词：
structural revision; stereoselective; synthesis; marine natural product; CYTOTOXIC CYCLIC DEPSIPEPTIDE; 1ST TOTAL-SYNTHESIS; SEA HARE; APLYSINA-GERARDOGREENI; LAURENCIA-MAJUSCULA; PALMEROLIDE-A; STEREOCHEMICAL REASSIGNMENT; ABSOLUTE-CONFIGURATION; ANTITUMOR METABOLITES; BIOLOGICAL-ACTIVITIES;
D O I：
10.3390/md7030314
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Because of the highly unique structures of marine natural products, there are many examples of structures that were originally proposed based on spectral analyses but later proven incorrect. In many cases, the total syntheses of the originally proposed structures of marine natural products has confirmed their incorrectness and the subsequent total syntheses of the newly proposed structures proved the revised structures. This review will show such cases appearing after 2005 and demonstrate how the true structures were elucidated.
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页码：314 / 330
页数：17
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