Current concepts in the assessment and treatment of Hepatic Encephalopathy

被引：82

作者：

Cash, W. J. ^{[1
]}

McConville, P. ^{[2
]}

McDermott, E. ^{[1
]}

McCormick, P. A. ^{[1
]}

Callender, M. E. ^{[2
]}

McDougall, N. I. ^{[2
]}

机构：

[1] St Vincents Univ Hosp, Natl Liver Transplant Unit, Dublin 4, Ireland

[2] Royal Victoria Hosp, Liver Unit, Belfast BT12 6BA, Antrim, North Ireland

来源：

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2010年 / 103卷 / 01期

关键词：

PORTAL-SYSTEMIC ENCEPHALOPATHY; RANDOMIZED CONTROLLED-TRIAL; DOUBLE-BLIND; ANTIBIOTIC-THERAPY; LIVER-DISEASE; LACTULOSE; RIFAXIMIN; PATHOPHYSIOLOGY; ACID; SUPPLEMENTATION;

D O I：

10.1093/qjmed/hcp152

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatic encephalopathy (HE) is defined as a metabolically induced, potentially reversible, functional disturbance of the brain that may occur in acute or chronic liver disease. Standardized nomenclature has been proposed but a standardized approach to the treatment, particularly of persistent, episodic and recurrent encephalopathy associated with liver cirrhosis has not been proposed. This review focuses on the pathogenesis and treatment of HE in patients with cirrhosis. The pathogenesis and treatment of hepatic encephalopathy in fulminant hepatic failure is quite different and is reviewed elsewhere.

引用

页码：9 / 16

页数：8

共 40 条

[1] Pathophysiology of hepatic encephalopathy: A new look at GABA from the molecular standpoint [J].

Ahboucha, S ;

Butterworth, RF .

METABOLIC BRAIN DISEASE, 2004, 19 (3-4) :331-343

[2] Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials [J].

Als-Nielsen, B ;

Gluud, LL ;

Gluud, C .

BMJ-BRITISH MEDICAL JOURNAL, 2004, 328 (7447) :1046-1050

[3] Probiotic yogurt for the treatment of minimal hepatic encephalopathy [J].

Bajaj, Jasmohan S. ;

Saeian, Kia ;

Christensen, Kenneth M. ;

Hafeezullah, Muhammad ;

Varma, Rajiv R. ;

Franco, Jose ;

Pleuss, Joan A. ;

Krakower, Glenn ;

Hoffmann, Raymond G. ;

Binion, David G. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (07) :1707-1715

[4] DEAFNESS COMPLICATING ANTIBIOTIC THERAPY OF HEPATIC ENCEPHALOPATHY [J].

BERK, DP ;

CHALMERS, T .

ANNALS OF INTERNAL MEDICINE, 1970, 73 (03) :393-+

[5] LACTITOL OR LACTULOSE IN THE TREATMENT OF CHRONIC HEPATIC-ENCEPHALOPATHY - RESULTS OF A METAANALYSIS [J].

BLANC, P ;

DAURES, JP ;

ROUILLON, JM ;

PERAY, P ;

PIERRUGUES, R ;

LARREY, D ;

GREMY, F ;

MICHEL, H .

HEPATOLOGY, 1992, 15 (02) :222-228

[6] DOUBLE-BLIND, DOUBLE-DUMMY COMPARISON BETWEEN TREATMENT WITH RIFAXIMIN AND LACTULOSE IN PATIENTS WITH MEDIUM TO SEVERE DEGREE HEPATIC-ENCEPHALOPATHY [J].

BUCCI, L ;

PALMIERI, GC .

CURRENT MEDICAL RESEARCH AND OPINION, 1993, 13 (02) :109-118

[7] Pathophysiology of hepatic encephalopathy: A new look at ammonia [J].

Butterworth, RF .

METABOLIC BRAIN DISEASE, 2002, 17 (04) :221-227

[8] LACTITOL IN TREATMENT OF CHRONIC HEPATIC-ENCEPHALOPATHY - A METAANALYSIS [J].

CAMMA, C ;

FIORELLO, F ;

TINE, F ;

MARCHESINI, G ;

FABBRI, A ;

PAGLIARO, L .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (05) :916-922

[9] INFLUENCE OF PHENYLETHANOLAMINE ON OCTOPAMINE PLASMA DETERMINATION IN HEPATIC ENCEPHALOPATHY [J].

CAPOCACCIA, L ;

CANGIANO, C ;

CASCINO, A ;

CALCATERRA, V ;

CARDELLI, P ;

FANELLI, FR .

CLINICA CHIMICA ACTA, 1979, 93 (03) :371-376

[10] Branched-chain amino acid enriched supplements as therapy for liver disease [J].

Charlton, M .

JOURNAL OF NUTRITION, 2006, 136 (01) :295S-298S

← 1 2 3 4 →