Transcranial magnetic stimulation over the right dorsolateral prefrontal cortex modulates visuospatial distractor suppression

Visual selective attention allows us to filter relevant inputs from irrelevant inputs during visual processing. In contrast to rich research exploring how the brain facilitates task-relevant inputs, less is known about how the brain suppresses irrelevant inputs. In this study, we used transcranial magnetic stimulation (TMS) to investigate the causal role of the right dorsolateral prefrontal cortex (DLPFC), a crucial brain area for attentional control, in distractor suppression. Specifically, 10-Hz repetitive TMS (rTMS) was applied to the right DLPFC and Vertex at the stimuli onset (stimuli-onset TMS) or 500 ms prior to the stimuli onset (prestimuli TMS). In a variant of the Posner cueing task, participants were instructed to identify the shape of a white target while ignoring a white or colored distractor whose location was either cued in advance or uncued. As anticipated, either the location cue or the colored distractor led to faster responses. Notably, the location cueing effect was eliminated by stimuli-onset TMS to the right DLPFC, but not by prestimuli TMS. Further analyses showed that stimuli-onset TMS quickened responses to uncued trials, and this TMS effect was derived from the inhibition at the distractor in both visual fields. In addition, TMS over the right DLPFC had no specific effect on the colored distractor compared to the white one. Considered collectively, these findings indicate that the DLPFC plays a crucial role in visuospatial distractor suppression and acts upon stimuli presentation. Besides, it seems the DLPFC contributes more to location-based distractor suppression than to color-based one.