Roles of Fc receptors in autoimmunity

被引:472
作者
Takai, T
机构
[1] Tohoku Univ, Dept Expt Immunol, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Inst Dev Ageing & Canc, Japan Sci & Technol Corp, Core Res Evolut Sci & Technol Programme, Sendai, Miyagi 9808575, Japan
关键词
D O I
10.1038/nri856
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The receptors for the Fc of immunoglobulins, Fc receptors (FcRs), link the humoral and cellular, branches of the immune system, and they have important functions in the activation and down-modulation of immune responses. Balanced signalling through activating and inhibitory FcRs regulates the activity of various cells in the immune system. Recent work in animal models indicates that the-development of many human autoimmune diseases might be caused by impairment of the FcR regulatory system. This review provides an overview of the mechanisms of FcR-based immune regulation and describes how autoimmune disease might result from its dysfunction.
引用
收藏
页码:580 / 592
页数:13
相关论文
共 126 条
  • [1] Fc receptors are critical for autoimmune inflammatory damage to the central nervous system in experimental autoimmune encephalomyelitis
    Abdul-Majid, KB
    Stefferl, A
    Bourquin, C
    Lassmann, H
    Linington, C
    Olsson, T
    Kleinau, S
    Harris, RA
    [J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2002, 55 (01) : 70 - 81
  • [2] The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells
    Aman, MJ
    Lamkin, TD
    Okada, H
    Kurosaki, T
    Ravichandran, KS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (51) : 33922 - 33928
  • [3] Fc receptor signaling and trafficking: a connection for antigen processing
    Amigorena, S
    Bonnerot, C
    [J]. IMMUNOLOGICAL REVIEWS, 1999, 172 : 279 - 284
  • [4] Ashman RF, 1996, J IMMUNOL, V157, P5
  • [5] DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
    Bakker, ABH
    Hoek, RM
    Cerwenka, A
    Blom, B
    Lucian, L
    McNeil, T
    Murray, R
    Phillips, JH
    Sedgwick, JD
    Lanier, LL
    [J]. IMMUNITY, 2000, 13 (03) : 345 - 353
  • [6] Fc-γRI-deficient mice show multiple alterations to inflammatory and immune responses
    Barnes, N
    Gavin, AL
    Tan, PS
    Mottram, P
    Koentgen, F
    Hogarth, PM
    [J]. IMMUNITY, 2002, 16 (03) : 379 - 389
  • [7] Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis
    Bolland, S
    Ravetch, JV
    [J]. IMMUNITY, 2000, 13 (02) : 277 - 285
  • [8] Genetic modifiers of systemic lupus erythematosus in FcγRIIB-/- mice
    Bolland, S
    Yim, YS
    Tus, K
    Wakeland, EK
    Ravetch, JV
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (09) : 1167 - 1174
  • [9] SHIP modulates immune receptor responses by regulating membrane association of Btk
    Bolland, S
    Pearse, RN
    Kurosaki, T
    Ravetch, JV
    [J]. IMMUNITY, 1998, 8 (04) : 509 - 516
  • [10] Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis
    Booth, JW
    Kim, MK
    Jankowski, A
    Schreiber, AD
    Grinstein, S
    [J]. EMBO JOURNAL, 2002, 21 (03) : 251 - 258