Ras and Nox: Linked signaling networks?

被引：18

作者：

Wu, Ru Feng ^{[1
]}

Terada, Lance S. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Div Pulm & Crit Care, Dallas, TX 75390 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2009年 / 47卷 / 09期

关键词：

Reactive oxidant species (ROS); Signal transduction; NADPH oxidase; Transformation; Apoptosis; MAPK; SMOOTH-MUSCLE-CELLS; GENERATING NADPH-OXIDASE; II TYPE-1 RECEPTOR; REACTIVE OXYGEN; ANGIOTENSIN-II; ENDOPLASMIC-RETICULUM; NAD(P)H OXIDASE; K-RAS; DICTYOSTELIUM-DISCOIDEUM; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/j.freeradbiomed.2009.05.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both Ras and Nox represent ancient gene families which control a broad range of cellular responses. Both families mediate signals governing motility. differentiation, and proliferation, and both inhabit overlapping subcellular microdomains. Yet little is known of the precise functional relationship between these two ubiquitous families. In this review. we examine the interface where these two large fields meet. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1276 / 1281

页数：6

共 86 条

[1] S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells [J].

Adachi, T ;

Pimentel, DR ;

Heibeck, T ;

Hou, XY ;

Lee, YJ ;

Jiang, BB ;

Ido, Y ;

Cohen, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (28) :29857-29862

[2] Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6 [J].

Adachi, Y. ;

Shibai, Y. ;

Mitsushita, J. ;

Shang, W. H. ;

Hirose, K. ;

Kamata, T. .

ONCOGENE, 2008, 27 (36) :4921-4932

[3] Reactive oxygen species and development in microbial eukaryotes [J].

Aguirre, J ;

Ríos-Momberg, M ;

Hewitt, D ;

Hansberg, W .

TRENDS IN MICROBIOLOGY, 2005, 13 (03) :111-118

[4] Reactive oxygen generated by Nox1 triggers the angiogenic switch [J].

Arbiser, JL ;

Petros, J ;

Klafter, R ;

Govindajaran, B ;

McLaughlin, ER ;

Brown, LF ;

Cohen, C ;

Moses, M ;

Kilroy, S ;

Arnold, RS ;

Lambeth, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :715-720

[5] Two novel proteins activate superoxide generation by the NADPH oxidase NOX1 [J].

Bánfi, B ;

Clark, RA ;

Steger, K ;

Krause, KH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (06) :3510-3513

[6] Redox-regulated signaling by lactosylceramide in the proliferation of human aortic smooth muscle cells [J].

Bhunia, AK ;

Han, H ;

Snowden, A ;

Chatterjee, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (25) :15642-15649

[7] PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis [J].

Bivona, TG ;

Quatela, SE ;

Bodemann, BO ;

Ahearn, IM ;

Soskis, MJ ;

Mor, A ;

Miura, J ;

Wiener, HH ;

Wright, L ;

Saba, SG ;

Yim, D ;

Fein, A ;

Perez de Castro, I ;

Li, C ;

Thompson, CB ;

Cox, AD ;

Philips, MR .

MOLECULAR CELL, 2006, 21 (04) :481-493

[8] Superoxide signalling required for multicellular development of Dictyostelium [J].

Bloomfield, G ;

Pears, C .

JOURNAL OF CELL SCIENCE, 2003, 116 (16) :3387-3397

[9] An NAD(P)H oxidase regulates growth and transcription in melanoma cells [J].

Brar, SS ;

Kennedy, TP ;

Sturrock, AB ;

Huecksteadt, TP ;

Quinn, MT ;

Whorton, AR ;

Hoidal, JR .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2002, 282 (06) :C1212-C1224

[10] NADPH oxidases NOX-1 and NOX-2 require the regulatory subunit NOR-1 to control cell differentiation and growth in Neurospora crassa [J].

Cano-Dominguez, Nallely ;

Alvarez-Delfin, Karen ;

Hansberg, Wilhelm ;

Aguirre, Jesus .

EUKARYOTIC CELL, 2008, 7 (08) :1352-1361

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