The role of myeloid-derived suppressor cells in rheumatoid arthritis: An update

被引：22

作者：

Navashenaq, Jamshid Gholizadeh ^{[1
,2
]}

Shabgah, Arezoo Gowhari ^{[2
,3
]}

Hedayati-Moghadam, Mahdiyeh ^{[4
,5
]}

Ariaee, Nazila ^{[6
]}

Mohammadi, Hamed ^{[7
,8
]}

Hemmatzadeh, Maryam ^{[9
,10
]}

Azhdari, Sara ^{[11
]}

Jamialahmadi, Tannaz ^{[12
,13
]}

Sathyapalan, Thozhukat ^{[14
]}

Sahebkar, Amirhossein ^{[15
,16
,17
,18
]}

机构：

[1] Bam Univ Med Sci, Noncommunicable Dis Res Ctr, Bam, Iran

[2] Bam Univ Med Sci, Sch Med, Student Res Comm, Bam, Iran

[3] Bam Univ Med Sci, Sch Med, Bam, Iran

[4] Jiroft Univ Med Sci, Sch Med, Dept Physiol, Jiroft, Iran

[5] Mashhad Univ Med Sci, Allergy Res Ctr, Mashhad, Iran

[6] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Sch Med, Karaj, Iran

[7] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

[8] Alborz Univ Med Sci, Sch Med, Dept Immunol, Karaj, Iran

[9] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[10] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[11] Bam Univ Med Sci, Sch Med, Dept Anat & Embryol, Bam, Iran

[12] Islamic Azad Univ, Quchan Branch, Dept Food Sci & Technol, Quchan, Iran

[13] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran

[14] Univ Hull, Acad Diabet Endocrinol & Metab, Hull York Med Sch, Kingston Upon Hull, N Humberside, England

[15] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Iran

[16] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran

[17] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland

[18] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

来源：

LIFE SCIENCES | 2021年 / 269卷

关键词：

MDSC; Rheumatoid arthritis; Inflammation; Autoimmunity; COLLAGEN-INDUCED ARTHRITIS; T-CELL; TRANSCRIPTION FACTORS; ACTIVATED MONOCYTES; SYNOVIAL-FLUID; IMMUNE CELLS; TH17; DIFFERENTIATION; INFLAMMATION; ANTAGONISTS;

D O I：

10.1016/j.lfs.2021.119083

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Rheumatoid arthritis (RA) is an autoimmune disease that generally affects the joints. In the late stages of the disease, it can be associated with several complications. Although the exact etiology of RA is unknown, various studies have been performed to understand better the immunological mechanisms involved in the pathogenesis of RA. At the onset of the disease, various immune cells migrate to the joints and increase the recruitment of immune cells to the joints by several immunological mediators such as cytokines and chemokines. The function of specific immune cells in RA is well-established. The shift of immune responses to Th1 or Th17 is one of the most essential factors in the development of RA. Myeloid-derived suppressor cells (MDSCs), as a heterogeneous population of myeloid cells, play a regulatory role in the immune system that inhibits T cell activity through several mechanisms. Various studies have been performed on the function of these cells in RA, which in some cases have yielded conflicting results. Therefore, the purpose of this review article is to comprehensively understand the pro-inflammatory and anti-inflammatory functions of MDSCs in the pathogenesis of RA.

引用

页数：12

共 116 条

[1] Prediction of Altered 3′-UTR miRNA-Binding Sites from RNA-Seq Data: The Swine Leukocyte Antigen Complex (SLA) as a Model Region [J].