Nitroglycerin in the Prevention of Post-ERCP Pancreatitis: A Meta-Analysis

被引：40
作者：
Shao, Li-Ming [1 ]
Chen, Qing-Yu [1 ]
Chen, Miao-Yan [1 ]
Cai, Jian-Ting [1 ]
机构：
[1] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou 310009, Zhejiang, Peoples R China
来源：
DIGESTIVE DISEASES AND SCIENCES | 2010年 / 55卷 / 01期
关键词：
Nitroglycerin; Post-ERCP pancreatitis; Meta-analysis; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; TRANSDERMAL GLYCERYL TRINITRATE; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; CLINICAL PHARMACOKINETICS; PROSPECTIVE MULTICENTER; THERAPEUTIC ERCP; RISK-FACTORS; COMPLICATIONS; SPHINCTER;
D O I：
10.1007/s10620-008-0709-9
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The objective of this research paper is to evaluate the effect of prophylactic nitroglycerin in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) by performing a meta-analysis of randomized controlled trials (RCTs). Electronic databases, including PubMed, EMBASE, the Cochrane library, and the Science Citation Index, were searched to retrieve relevant trials. Outcome measures were the incidence of PEP. Four RCTs, enrolling a total of 856 patients, were included. Meta-analysis of these trials indicated a significant association between the use of nitroglycerin and the reduction of PEP (RR 0.60; 95% CI: 0.39-0.92; P = 0.02). However, subsequent sensitive analysis failed to confirm that nitroglycerin was statistically superior to a placebo in reducing PEP (RR 0.68; 95% CI: 0.41-1.11; P = 0.12). Based on the limitations in this meta-analysis, prophylactic use of nitroglycerine for all patients who underwent ERCP is not recommended. Further clinical trials are required to confirm the effect of nitroglycerin in the prevention of PEP.
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页码：1 / 7
页数：7
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