Synthesis of tetrazines from gem-difluoroalkenes under aerobic conditions at room temperature

被引：19

作者：

Fang, Zheng ^{[1
]}

Hu, Wen-Li ^{[1
]}

Liu, De-Yong ^{[1
]}

Yu, Chu-Yi ^{[1
,2
]}

Hu, Xiang-Guo ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China

[2] Chinese Acad Sci, BNLMS, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China

来源：

GREEN CHEMISTRY | 2017年 / 19卷 / 05期

关键词：

CHEMISTRY; 1,2,4,5-TETRAZINES; MONOFLUOROALKENES; CYCLOADDITIONS; FLUORINATION; LIGATION; REAGENTS; FLUORIDE; ACCESS; BOND;

D O I：

10.1039/c6gc03494b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and green procedure for the synthesis of tetrazines has been developed based on an old chemistry reported by Carboni in 1958. Both symmetric and asymmetric 3,6-disubstituted 1,2,4,5-tetrazines can be obtained in moderate to high yields from the corresponding gem-difluoroalkenes under aerobic conditions at room temperature. This work represents a rare example that ambient air is utilized as an oxidant for the synthesis of tetrazines.

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页码：1299 / 1302

页数：4

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