Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene

被引：205

作者：

Bianco, Suzy D. C.

Peng, Ji-Bin

Takanaga, Hitomi

Suzuki, Yoshiro

Crescenzi, Alessandra

Kos, Claudine H.

Zhuang, Liyan

Freeman, Michael R.

Gouveia, Cecilia H. A.

Wu, Jiangping

Luo, Hongyu

Mauro, Theodora

Brown, Edward M.

Hediger, Matthias A.

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Membrane Biol Program, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

[3] Childrens Hosp, Urol Dis Res Ctr, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA 02115 USA

[5] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, Sao Paulo, Brazil

[6] Univ Montreal, Ctr Hosp, Ctr Rech, Immunol Lab, Montreal, PQ, Canada

[7] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

[8] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Endocrinol Diabet & Metab, Boston, MA 02115 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 02期

关键词：

intestinal calcium absorption; renal excretion; TRPV6; alopecia; vitamin D;

D O I：

10.1359/JBMR.061110

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca2+ homeostasis, including defective intestinal Ca2+ absorption, increased urinary Ca2+ excretion, decreased BMD, deficient weight gain, and reduced fertility. Although our Trpv6 KO affects the closely adjacent EphB6 gene, the phenotype reported here is not related to EphB6 dysfunction.

引用

页码：274 / 285

页数：12

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