Prospects for a Zika Virus Vaccine

被引：73

作者：

Barouch, Dan H. ^{[1
,2
]}

Thomas, Stephen J. ^{[3
]}

Michael, Nelson L. ^{[4
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Harvard Med Sch, Boston, MA 02215 USA

[2] Ragon Inst MGH MIT Harvard, Cambridge, MA 02139 USA

[3] State Univ New York, Upstate Med Univ, Syracuse, NY 13210 USA

[4] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD 20910 USA

来源：

IMMUNITY | 2017年 / 46卷 / 02期

关键词：

ANTIBODY-DEPENDENT ENHANCEMENT; BORNE ENCEPHALITIS-VIRUS; GUILLAIN-BARRE-SYNDROME; TETRAVALENT DENGUE VACCINE; JAPANESE ENCEPHALITIS; PROTECTIVE EFFICACY; CROSS-REACTIVITY; STRUCTURAL BASIS; BIRTH-DEFECTS; INFECTION;

D O I：

10.1016/j.immuni.2017.02.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development. We discuss different vaccination strategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.

引用

页码：176 / 182

页数：7

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