COVID-19 in Adults With Congenital Heart Disease

被引：59

作者：

Broberg, Craig S. ^{[1
]}

Kovacs, Adrienne H. ^{[1
]}

Sadeghi, Soraya ^{[2
]}

Rosenbaum, Marlon S. ^{[3
]}

Lewis, Matthew J. ^{[3
]}

Carazo, Matthew R. ^{[4
]}

Rodriguez, Fred H., III ^{[4
]}

Halpern, Dan G. ^{[5
]}

Feinberg, Jodi ^{[5
]}

Arancibia Galilea, Francisca ^{[6
]}

Baraona, Fernando ^{[6
]}

Cedars, Ari M. ^{[7
]}

Ko, Jong M. ^{[7
]}

Porayette, Prashob ^{[8
]}

Maldonado, Jennifer ^{[8
]}

Sarubbi, Berardo ^{[9
]}

Fusco, Flavia ^{[9
]}

Frogoudaki, Alexandra A. ^{[10
]}

Nir, Amiram ^{[11
]}

Chaudhry, Anisa ^{[12
]}

John, Anitha S. ^{[13
]}

Karbassi, Arsha ^{[14
]}

Hoskoppal, Arvind K. ^{[15
]}

Frischhertz, Benjamin P. ^{[16
]}

Hendrickson, Benjamin ^{[17
]}

Bouma, Berto J. ^{[18
]}

Rodriguez-Monserrate, Carla P. ^{[19
]}

Broda, Christopher R. ^{[20
]}

Tobler, Daniel ^{[21
]}

Gregg, David ^{[22
]}

Martinez-Quintana, Efren ^{[23
]}

Yeung, Elizabeth ^{[24
]}

Krieger, Eric, V ^{[25
]}

Ruperti-Repilado, Francisco J. ^{[26
]}

Giannakoulas, George ^{[27
]}

Lui, George K. ^{[28
]}

Ephrem, Georges ^{[29
]}

Singh, Harsimran S. ^{[30
]}

Almeneisi, Hassan M. K. ^{[31
]}

Bartlett, Heather L. ^{[32
]}

Lindsay, Ian ^{[33
]}

Grewal, Jasmine ^{[34
]}

Nicolarsen, Jeremy ^{[35
]}

Araujo, John J. ^{[36
]}

Cramer, Jonathan W. ^{[37
]}

Bouchardy, Judith ^{[38
]}

Al Najashi, Khalid ^{[39
]}

Ryan, Kristi ^{[40
]}

Alshawabkeh, Laith ^{[41
]}

Andrade, Lauren ^{[42
]}

机构：

[1] Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Portland, OR 97201 USA

[2] Ahmanson UCLA Adult Congenital Heart Ctr, Los Angeles, CA USA

[3] Columbia Univ, Med Ctr, Div Cardiol, New York, NY USA

[4] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA USA

[5] York Univ Langone Hlth, Div Cardiol, New York, NY USA

[6] Pontificia Univ Catolica Chile, Inst Nacl Torax, Santiago, Chile

[7] Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD USA

[8] Univ Iowa, Stead Family Childrens Hosp, Div Cardiol, Iowa City, IA USA

[9] Monaldi Hosp, Adult Congenital Heart Dis Unit, Naples, Italy

[10] ATTIKON Univ Hosp, Cardiol Dept 2, Athens, Greece

[11] Shaare Zedek Med Ctr, Jerusalem, Israel

[12] Penn State Hershey Heart & Vasc Inst, State Coll, PA USA

[13] Childrens Natl Hosp, Div Cardiol, Washington, DC USA

[14] McMaster Univ, Hamilton, ON, Canada

[15] UPMC Adult Congenital Heart Dis Program, Pittsburgh, PA USA

[16] Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Nashville, TN USA

[17] Univ Tennessee, Hlth Sci Ctr, Le Bonheur Heart Inst, Memphis, TN 38163 USA

[18] Univ Amsterdam, Med Ctr, Dept Cardiol, Amsterdam, Netherlands

[19] Boston Childrens Hosp, Dept Cardiol, Boston, MA USA

[20] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[21] Univ Hosp Basel, Div Cardiol, Basel, Switzerland

[22] Med Univ South Carolina, Div Cardiol, Charleston, SC USA

[23] Univ Insular Materno Infantil, Cardiol Serv, Las Palmas Gran Canaria, Spain

[24] Colorados Adult & Teen Congenital Heart Program, Anschutz Med Campus, Aurora, CO USA

[25] Univ Washington, Sch Med, Div Cardiol, Seattle, WA USA

[26] Univ Hosp Geneva, Div Cardiol, Geneva, Switzerland

[27] AHEPA Univ Hosp, Cardiol Dept, Thessaloniki, Greece

[28] Stanford Univ, Sch Med, Div Cardiovasc Med & Pediat Cardiol, Stanford, CA 94305 USA

[29] Indiana Univ Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA

[30] New York Presbyterian Hosp, Dept Med & Pediat, Weill Cornell Med, New York, NY USA

[31] Cincinnati Childrens Hosp Med Ctr, Heart Inst, Cincinnati, OH 45229 USA

[32] Univ Wisconsin, Dept Pediat & Med, Madison, WI USA

[33] Univ Utah, Div Pediat Cardiol, Salt Lake City, UT USA

[34] Univ British Columbia, St Pauls Hosp, Vancouver, BC, Canada

[35] Providence Adult & Teen Congenital Heart Program, Pediat & Adult Cardiol, Spokane, WA USA

[36] Somer Incare Cardiovasc Ctr, Dept Pediat & Adult Congenital Heart Dis, Rionegro, Colombia

[37] Univ Nebraska Med Ctr, Div Cardiovasc Med, Omaha, NE USA

[38] Univ Hosp Lausanne, Dept Cardiol & Cardiac Surg, Lausanne, Switzerland

[39] Prince Sultan Cardiac Ctr, Pediat Cardiol Dept, Riyadh, Saudi Arabia

[40] OSF Healthcare Childrens Hosp Illinois, Adult Congenital Heart Program, Peoria, IL USA

[41] Univ Calif San Diego, Dept Cardiovasc Med, La Jolla, CA 92093 USA

[42] Hosp Univ Penn, Div Cardiol, 3400 Spruce St, Philadelphia, PA 19104 USA

[43] Hop Europeen Georges Pompidou, Adult Congenital Heart Dis Unit, Paris, France

[44] Univ Hosp Inselspital, Ctr Congenital Heart Dis, Bern, Switzerland

[45] Univ Zurich, Dept Cardiol, Zurich, Switzerland

[46] Univ Hosp La Paz, Madrid, Spain

[47] Univ Milan, Cardiovasc Dept, ASST Papa Giovanni 23, Bergamo, Italy

[48] Univ Saskatchewan, Prairie Vasc Res Network, Regina, SK, Canada

[49] Univ Texas Houston, Adult Congenital Heart Dis, Houston, TX USA

[50] Hosp Univ Virgen de las Nieves, Cardiol Dept, Granada, Spain

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2021年 / 77卷 / 13期

关键词：

adult congenital heart disease; coronavirus; COVID-19; hospitalization; UNITED-STATES; RISK; HOSPITALIZATION; CONSEQUENCES; INFLUENZA;

D O I：

10.1016/j.jacc.2021.02.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications. OBJECTIVES This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes. METHODS Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide. Data collection included anatomic diagnosis and subsequent interventions, comorbidities, medications, echocardiographic findings, presenting symptoms, course of illness, and outcomes. Predictors of death or severe infection were determined. RESULTS From 58 adult CHD centers, the study included 1,044 infected patients (age: 35.1 +/- 13.0 years; range 18 to 86 years; 51% women), 87% of whom had laboratory-confirmed coronavirus infection. The cohort included 118 (11%) patients with single ventricle and/or Fontan physiology, 87 (8%) patients with cyanosis, and 73 (7%) patients with pulmonary hypertension. There were 24 COVID-related deaths (case/fatality: 2.3%; 95% confidence interval: 1.4% to 3.2%). Factors associated with death included male sex, diabetes, cyanosis, pulmonary hypertension, renal insufficiency, and previous hospital admission for heart failure. Worse physiological stage was associated with mortality (p = 0.001), whereas anatomic complexity or defect group were not. CONCLUSIONS COVID-19 mortality in adults with CHD is commensurate with the general population. The most vulnerable patients are those with worse physiological stage, such as cyanosis and pulmonary hypertension, whereas anatomic complexity does not appear to predict infection severity. (C) 2021 by the American College of Cardiology Foundation.

引用

页码：1644 / 1655

页数：12

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