Potential compounds from several Indonesian plants to prevent SARS-CoV-2 infection: A mini-review of SARS-CoV-2 therapeutic targets

被引：11

作者：

Illian, Didi Nurhadi ^{[1
]}

Siregar, Etti Sartina ^{[2
]}

Sumaiyah, Sumaiyah ^{[3
]}

Utomo, Ahmad Rusdan ^{[4
]}

Nuryawan, Arif ^{[5
,6
]}

Basyuni, Mohammad ^{[5
,6
]}

机构：

[1] Univ Syiah Kuala, Fac Math & Nat Sci, Dept Pharm, Banda Aceh 23111, Indonesia

[2] Univ Sumatera Utara, Fac Math & Nat Sci, Dept Biol, Medan 20155, Indonesia

[3] Univ Sumatera Utara, Dept Technol Pharm, Fac Pharm, Medan 20155, Indonesia

[4] Perhimpunan Biol Med Indonesia PBMI, Medan, Indonesia

[5] Univ Sumatera Utara, Dept Forestry, Fac Forestry, Medan 20155, Indonesia

[6] Univ Sumatera Utara, Ctr Excellence Mangrove, Medan 20155, Indonesia

来源：

HELIYON | 2021年 / 7卷 / 01期

关键词：

COVID-19; SARS-CoV-2; Therapeutic target; Emodin; Luteolin; Mangroves; SYNDROME CORONAVIRUS INFECTION; COV 3CL PROTEASE; SPIKE PROTEIN; ANTIPROLIFERATIVE ACTIVITY; MANGROVE PLANT; SARS; FLAVONOIDS; ACE2; EMODIN; CONSTITUENTS;

D O I：

10.1016/j.heliyon.2021.e06001

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The outbreak of coronaviruses (CoVs) presents an enormous threat to humans. To date, no new therapeutic drugs or vaccines licensed to treat human coronaviruses remain undiscovered. This mini-review briefly reports the number of potential plants widely distributed in Indonesia for further research and development as anti-SARS-CoV-2 agents and the critical targets for SARS-CoV-2 therapy, such as angiotensin-converting enzyme 2 (ACE-2) receptor, spike protein, 3-chymotrypsin-like protease (3CL(pro)), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), helicase, and serine protease. Indonesia is rich in medicinal plants (herbal); it also has a long history of using plants to treat various hereditary diseases. However, since SARS-CoV-2 is a new disease, it has no history of plant-based treatment anywhere in the world. This mini-review describes natural products from several Indonesian plants that contain compounds that could potentially prevent or reduce SARS-CoV-2 infection, act as potential targeted therapy, and provide new therapeutic strategies to develop SARS-CoV-2 countermeasures.

引用

页数：11

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