Visible-Light-Mediated Cross-Couplings and C-H Activation via Dual Photoredox/Transition-Metal Catalysis in Continuous-Flow Processes

被引：10

作者：

Kim, Soo Dong ^{[1
]}

Lee, Jonghyun ^{[1
]}

Kim, Nam-Jung ^{[1
]}

Park, Boyoung Y. ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Seoul 02447, South Korea

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 8卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

photochemical transformations; cross-coupling; C-H activation; continuous-flow processes; SINGLE-ELECTRON TRANSMETALATION; PHOTOREDOX CATALYSIS; PALLADIUM CATALYSIS; NICKEL CATALYSIS; ARYL BROMIDES; GENERATION; SILICATES; ACYLATION; BATCH; FUNCTIONALIZATION;

D O I：

10.1002/ajoc.201900354

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we review dual photoredox/transition-metal catalysis for C-C/C-N cross-couplings and C-H activation in continuous-flow processes. Compared to conventional transition-metal catalysis for these reactions, visible-light-mediated synergistic catalysis enables the use of relatively mild and environmentally friendly reaction conditions by decreasing the activation energy and using a renewable energy source. However, photochemical transformations in batch processing have limitations such as reactivity, reaction time, substrate scope, and scalability due to light attenuation as represented by the Beer-Lambert law. In this review article, we therefore summarize and discuss several examples of cross-couplings and C-H activation in continuous-flow processes that overcome these problems in batch processing.

引用

页码：1578 / 1587

页数：10

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