Vitamin D receptor variants and the malignant melanoma risk: A population-based study

被引：32

作者：

Gapska, P. ^{[1
]}

Scott, R. J. ^{[2
,6
]}

Serrano-Fernandez, P. ^{[1
]}

Mirecka, A. ^{[1
]}

Rassoud, I. ^{[1
]}

Gorski, B. ^{[1
]}

Cybulski, C. ^{[1
]}

Huzarski, T. ^{[1
]}

Byrski, T. ^{[1
]}

Nagay, L. ^{[3
]}

Maleszka, R. ^{[4
]}

Sulikowski, M. ^{[5
]}

Lubinski, J. ^{[1
]}

Debniak, T. ^{[1
]}

机构：

[1] Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland

[2] Univ Newcastle, Fac Hlth, Discipline Med Genet, Newcastle, NSW 2308, Australia

[3] Reg Oncol Hosp, Szczecin, Poland

[4] Pomeranian Med Univ, Dept Dermatol & Venerol, PL-70115 Szczecin, Poland

[5] Pomeranian Med Univ, Clin Maxillofacial Surg, PL-70115 Szczecin, Poland

[6] Hunter Med Res Inst, Newcastle, NSW, Australia

来源：

CANCER EPIDEMIOLOGY | 2009年 / 33卷 / 02期

关键词：

Malignant melanoma; Vitamin D receptor; CUTANEOUS MELANOMA; GENE POLYMORPHISMS; COMMON VARIANTS; CANCER; ASSOCIATION; HAPLOTYPES; EXPRESSION; MUTATIONS; GENOTYPES; TISSUE;

D O I：

10.1016/j.canep.2009.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: There is continuing interest in identifying low-penetrance genes which are associated with an increased susceptibility to common types of cancer, including malignant melanoma. Methods: We sought to examine the association between four VDR common variants (rs1544410, rs731236, rs10735810, rs4516035) and the risk of melanoma in the Polish population. We also determined the prevalence of compound carriers of VDR and known MM genetic risk factors MC1R and CDKN2A (A148T) variants. We examined 763 unselected melanoma cases, 763 healthy adults matched for sex and age with the melanoma cases and 777 newborns. Results: None of the VDR variants alone or as compound carriers of two or more of the VDR genotypes were associated with MM risk. There were no major differences between the prevalences of the examined variants among patients with MM on UV-exposed and UV-non exposed skin areas, as well as among early-onset and late-onset cases. We found no association between VDR and MC1R or between VDR and CDKN2A common variants. A statistically significant over-re presentation of one VDR haplotype: rs731236_A + rs1544410_T (OR = 3.2, p = 0.02) was detected. Linkage disequilibrium of rs1544410 and rs731236 was confirmed. Conclusion: To answer the question, whether VDR can be regarded as melanoma susceptibility gene, additional, large multicenter association studies have to be performed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：103 / 107

页数：5

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