PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

被引：390
作者：
Grossen, Philip [1 ]
Witzigmann, Dominik [1 ]
Sieber, Sandro [1 ]
Huwyler, Jorg [1 ]
机构：
[1] Univ Basel, Div Pharmaceut Technol, Dept Pharmaceut Sci, Basel, Switzerland
来源：
JOURNAL OF CONTROLLED RELEASE | 2017年 / 260卷
基金：
瑞士国家科学基金会;
关键词：
Nanomedicine; Nanoparticle; Polymer; Peg-PCL; Drug delivery; Drug targeting; RING-OPENING POLYMERIZATION; ANTI-GLIOBLASTOMA EFFICACY; BLOCK-COPOLYMER MICELLES; TUMOR TARGETED DELIVERY; IN-VIVO DEGRADATION; POLY(ETHYLENE GLYCOL); EPSILON-CAPROLACTONE; BRAIN DELIVERY; PARTICLE-SIZE; TRIBLOCK COPOLYMERS;
D O I：
10.1016/j.jconrel.2017.05.028
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly( ethylene glycol)-poly(epsilon-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at the site of action and decreased off-target effects. In this review, we discuss state-of-the-art nanomedicines based on PEG-PCL that have been investigated in a preclinical setting. We summarize the various synthesis routes and different preparation methods used for the production of PEG-PCL nanoparticles. Additionally, we review physico-chemical properties including biodegradability, biocompatibility, and drug loading. Finally, we highlight recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi-component therapies, theranostics, or gene delivery systems.
引用
收藏
页码：46 / 60
页数：15
相关论文
共 254 条
[1]   Freeze-drying of nanoparticles: Formulation, process and storage considerations [J].
Abdelwahed, Wassim ;
Degobert, Ghania ;
Stainmesse, Serge ;
Fessi, Hatem .
ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (15) :1688-1713
[2]   The liposomal formulation of doxorubicin [J].
Abraham, SA ;
Waterhouse, DN ;
Mayer, LD ;
Cullis, PR ;
Madden, TD ;
Bally, MB .
LIPOSOMES, PT E, 2005, 391 :71-97
[3]  
ABUCHOWSKI A, 1977, J BIOL CHEM, V252, P3578
[4]   Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles [J].
Ahmed, F ;
Discher, DE .
JOURNAL OF CONTROLLED RELEASE, 2004, 96 (01) :37-53
[5]   PCL-PEG graft copolymers with tunable amphiphilicity as efficient drug delivery systems [J].
Al Samad, A. ;
Bethry, A. ;
Koziolova, E. ;
Netopilik, M. ;
Etrych, T. ;
Bakkour, Y. ;
Coudane, J. ;
El Omar, F. ;
Nottelet, B. .
JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (37) :6228-6239
[6]   Factors affecting the clearance and biodistribution of polymeric nanoparticles [J].
Alexis, Frank ;
Pridgen, Eric ;
Molnar, Linda K. ;
Farokhzad, Omid C. .
MOLECULAR PHARMACEUTICS, 2008, 5 (04) :505-515
[7]   Encapsulation of hydrophobic drugs in polymeric micelles through co-solvent evaporation: The effect of solvent composition on micellar properties and drug loading [J].
Aliabadi, Hamidfeza Montazeri ;
Elhasi, Sara ;
Mahmud, Abdullah ;
Gulamhusein, Rashida ;
Mahdipoor, Parvin ;
Lavasanifar, Afsaneh .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 329 (1-2) :158-165
[8]   Polymeric micellar delivery reduces kidney distribution and nephrotoxic effects of cyclosporine A after multiple dosing [J].
Aliabadi, Hamidreza Montazeri ;
Elhasi, Sara ;
Brocks, Dion R. ;
Lavasanifar, Afsaneh .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (05) :1916-1926
[9]   A novel use of an in vitro method to predict the in vivo stability of block copolymer based nano-containers [J].
Aliabadi, Hamidreza Montazeri ;
Brocks, Dion R. ;
Mahdipoor, Parvin ;
Lavasanifar, Afsaneh .
JOURNAL OF CONTROLLED RELEASE, 2007, 122 (01) :63-70
[10]   Micelles of methoxy poly(ethylene oxide)-b-poly(ε-caprolactone) as vehicles for the solubilization and controlled delivery of Cyclosporine A [J].
Aliabadi, HM ;
Mahmud, A ;
Sharifabadi, AD ;
Lavasanifar, A .
JOURNAL OF CONTROLLED RELEASE, 2005, 104 (02) :301-311
12345678910