Functional imaging for early prediction of response to chemoradiotherapy:: 3′-deoxy-3′-18F-fluorothymidine positron emission tomography -: A clinical application model of esophageal cancer

被引：13

作者：

Chao, K. S. Clifford ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

SEMINARS IN ONCOLOGY | 2006年 / 33卷 / 06期

关键词：

D O I：

10.1053/j.seminoncol.2006.10.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pathologic complete response after neoadjuvant chemoradiation therapy is associated with increased survival in esophageal cancer. Early detection of response or nonresponse to neoadjuvant chemoradiation might allow individualization of treatment strategies and avoidance of unnecessary treatment. Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) permits detection of changes in tumor proliferation before any change in tumor size occurs, and FDG-PET findings have been correlated with outcomes in esophageal cancer. However, FDG-PET may fail to distinguish between residual tumor and inflammation and between complete response and partial response with substantial residual tumor burden. PET with the nucleoside analogue 3′-deoxy-3′-18F-fluorothymidine (FLT) has been found to be more accurate than FDG-PET in visualizing early changes in tumor proliferation. In a recent study in experimental models of esophageal cancer, FLT-PET was more accurate than FDG-PET in detecting early changes in proliferation following docetaxel and radiation therapy in human SEG-1 cells and mouse SEG-1 xenografts, including having a much stronger correlation with histologic findings. Clinical studies are needed to determine if FLT-PET can distinguish among degrees of response to neoadjuvant chemoradiation in patients with esophageal cancer. © 2006 Elsevier Inc. All rights reserved.

引用

页码：S59 / S63

页数：5

共 19 条

[1] Early detection of chemoradioresponse in esophageal carcinoma by 3′-deoxy-3′-3H-fluorothymidine using preclinical tumor models [J].

Apisarnthanarax, Smith ;

Alauddin, Mian M. ;

Mourtada, Firas ;

Ariga, Hisanori ;

Raju, Uma ;

Mawlawi, Osama ;

Han, Dongmei ;

Bornmann, William G. ;

Ajani, Jaffer A. ;

Milas, Luka ;

Gelovani, Juri G. ;

Chao, K. S. Clifford .

CLINICAL CANCER RESEARCH, 2006, 12 (15) :4590-4597

[2]

Arslan Nuri, 2002, Mol Imaging Biol, V4, P301, DOI 10.1016/S1536-1632(02)00011-2

[3]

Barthel H, 2003, CANCER RES, V63, P3791

[4] Complete response to neoadjuvant chemoradiotherapy in esophageal carcinoma is associated with significantly improved survival [J].

Berger, AC ;

Farma, J ;

Scott, WJ ;

Freedman, G ;

Weiner, L ;

Cheng, JD ;

Wang, H ;

Goldberg, M .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (19) :4330-4337

[5]

Buck AK, 2003, J NUCL MED, V44, P1426

[6] Detection and grading of soft tissue sarcomas of the extremities with 18F-3′-fluoro-3′-deoxy-L-thymidine [J].

Cobben, DCP ;

Elsinga, PH ;

Suurmeijer, AJH ;

Vaalburg, W ;

Maas, B ;

Jager, PL ;

Hoekstra, HJ .

CLINICAL CANCER RESEARCH, 2004, 10 (05) :1685-1690

[7] In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography [J].

Francis, DL ;

Freeman, A ;

Visvikis, D ;

Costa, DC ;

Luthra, SK ;

Novelli, M ;

Taylor, I ;

Ell, PJ .

GUT, 2003, 52 (11) :1602-1606

[8]

KUBOTA R, 1992, J NUCL MED, V33, P1972

[9] Early detection of tumor response to chemotherapy by 3′-deoxy-3′-[18 F]fluorothymidine positron emission tomography:: The effect of cisplatin on a fibrosarcoma tumor model in vivo [J].

Leyton, J ;

Latigo, JR ;

Perumal, M ;

Dhaliwal, H ;

He, QM ;

Aboagye, EO .

CANCER RESEARCH, 2005, 65 (10) :4202-4210

[10]

Nakamura Ryuji, 2002, Radiat Med, V20, P181

← 1 2 →