Analogues of 2-crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone (COTC) with anti-tumor properties

被引：16

作者：

Arthurs, Claire L.

Wind, Natasha S.

Whitehead, Roger C.

Stratford, Ian J.

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[2] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 02期

基金：

英国医学研究理事会;

关键词：

anti-tumor; natural product; synthetic analogue; glutathione transferase; organo-fluorine;

D O I：

10.1016/j.bmcl.2006.09.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses of three novel analogues of the naturally occurring cytotoxic agent COTC are described and the results of bioassays of the target compounds against two lung cancer cell lines are presented. (c) 2006 Published by Elsevier Ltd.

引用

页码：553 / 557

页数：5

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