The enigmatic parietal epithelial cell is finally getting noticed: a review

被引：58

作者：

Ohse, Takamoto ^{[1
]}

Pippin, Jeffrey W. ^{[1
]}

Chang, Alice M. ^{[1
]}

Krofft, Ronald D. ^{[1
]}

Miner, Jeffrey H. ^{[2
,3
]}

Vaughan, Michael R. ^{[1
]}

Shankland, Stuart J. ^{[1
]}

机构：

[1] Univ Washington, Div Nephrol, Dept Med, Seattle, WA 98195 USA

[2] Washington Univ, Sch Med, Dept Internal Med, Div Renal, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

KIDNEY INTERNATIONAL | 2009年 / 76卷 / 12期

关键词：

albuminuria; glomerulus; parietal epithelial cells; podocytes; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; TISSUE GROWTH-FACTOR; EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS; GLOMERULAR CRESCENT FORMATION; INTRINSIC RENAL-CELLS; ADULT HUMAN KIDNEY; BASEMENT-MEMBRANE; DIFFERENTIAL EXPRESSION; RAT-KIDNEY; COLLAPSING GLOMERULOPATHY;

D O I：

10.1038/ki.2009.386

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Although the normal glomerulus comprises four resident cell types, least is known about the parietal epithelial cells (PECs). This comprehensive review addresses the cellular origin of PECs, discusses the normal structure and protein makeup of PECs, describes PEC function, and defines the responses to injury in disease and how these events lead to clinical events. The data show that PECs have unique properties and that new functions are being recognized such as their role in differentiating into podocytes during disease. Kidney International (2009) 76, 1225-1238; doi:10.1038/ki.2009.386; published online 21 October 2009

引用

页码：1225 / 1238

页数：14

共 120 条

[71] Phenotypic characteristics and cyclin-dependent kinase inhibitors repression in hyperplastic epithelial pathology in idiopathic focal segmental glomerulosclerosis [J].

Nagata, M ;

Horita, S ;

Shu, YJ ;

Shibata, S ;

Hattori, M ;

Ito, K ;

Watanabe, T .

LABORATORY INVESTIGATION, 2000, 80 (06) :869-880

[72]

NAKOPOULOU L, 1994, NEPHROL DIAL TRANSPL, V9, P764

[73] SCG/Kinjoh mice:: A model of ANCA-associated crescentic glomerulonephritis with immune deposits [J].

Neumann, I ;

Birck, R ;

Newman, M ;

Schnülle, P ;

Kriz, W ;

Nemoto, K ;

Yard, B ;

Waldherr, R ;

van der Woude, FJ .

KIDNEY INTERNATIONAL, 2003, 64 (01) :140-148

[74] Glomerular epithelial-myofibroblast transdifferentiation in the evolution of glomerular crescent formation [J].

Ng, YY ;

Fan, JM ;

Mu, W ;

Nikolic-Paterson, DJ ;

Yang, WC ;

Huang, TP ;

Atkins, RC ;

Lan, HY .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (12) :2860-2872

[75] DIFFERENTIAL EXPRESSION OF 2 BASEMENT-MEMBRANE COLLAGEN GENES, COL4A6 AND COL4A5, DEMONSTRATED BY IMMUNOFLUORESCENCE STAINING USING PEPTIDE-SPECIFIC MONOCLONAL-ANTIBODIES [J].

NINOMIYA, Y ;

KAGAWA, M ;

IYAMA, K ;

NAITO, I ;

KISHIRO, Y ;

SEYER, JM ;

SUGIMOTO, M ;

OOHASHI, T ;

SADO, Y .

JOURNAL OF CELL BIOLOGY, 1995, 130 (05) :1219-1229

[76] Glomerular expression of cell-cycle-regulatory proteins in human crescentic glomerulonephritis [J].

Nitta, B ;

Horita, S ;

Honda, K ;

Uchida, K ;

Watanabe, T ;

Nihei, H ;

Nagata, M .

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 1999, 435 (04) :422-427

[77]

Oda T, 1997, J PATHOL, V183, P359

[78]

OHSE T, NEW FUNCTIO IN PRESS

[79] Establishment of conditionally immortalized mouse glomerular parietal epithelial cells in culture [J].

Ohse, Takamoto ;

Pippin, Jeffrey W. ;

Vaughan, Michael R. ;

Brinkkoetter, Paul T. ;

Krofft, Ronald D. ;

Shankland, Stuart J. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (10) :1879-1890

[80] Role of intrinsic renal cells versus infiltrating cells in glomerular crescent formation [J].

Ophascharoensuk, V ;

Pippin, JW ;

Gordon, KL ;

Shankland, SJ ;

Couser, WG ;

Johnson, RJ .

KIDNEY INTERNATIONAL, 1998, 54 (02) :416-425

← 3 4 5 6 7 8 9 10 11 12 →