The enigmatic parietal epithelial cell is finally getting noticed: a review

被引：58

作者：

Ohse, Takamoto ^{[1
]}

Pippin, Jeffrey W. ^{[1
]}

Chang, Alice M. ^{[1
]}

Krofft, Ronald D. ^{[1
]}

Miner, Jeffrey H. ^{[2
,3
]}

Vaughan, Michael R. ^{[1
]}

Shankland, Stuart J. ^{[1
]}

机构：

[1] Univ Washington, Div Nephrol, Dept Med, Seattle, WA 98195 USA

[2] Washington Univ, Sch Med, Dept Internal Med, Div Renal, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

KIDNEY INTERNATIONAL | 2009年 / 76卷 / 12期

关键词：

albuminuria; glomerulus; parietal epithelial cells; podocytes; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; TISSUE GROWTH-FACTOR; EXPERIMENTAL AUTOIMMUNE GLOMERULONEPHRITIS; GLOMERULAR CRESCENT FORMATION; INTRINSIC RENAL-CELLS; ADULT HUMAN KIDNEY; BASEMENT-MEMBRANE; DIFFERENTIAL EXPRESSION; RAT-KIDNEY; COLLAPSING GLOMERULOPATHY;

D O I：

10.1038/ki.2009.386

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Although the normal glomerulus comprises four resident cell types, least is known about the parietal epithelial cells (PECs). This comprehensive review addresses the cellular origin of PECs, discusses the normal structure and protein makeup of PECs, describes PEC function, and defines the responses to injury in disease and how these events lead to clinical events. The data show that PECs have unique properties and that new functions are being recognized such as their role in differentiating into podocytes during disease. Kidney International (2009) 76, 1225-1238; doi:10.1038/ki.2009.386; published online 21 October 2009

引用

页码：1225 / 1238

页数：14

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