Osteochondromas: An Updated Review of Epidemiology, Pathogenesis, Clinical Presentation, Radiological Features and Treatment Options

被引:61
|
作者
Tepelenis, Kostas [1 ]
Papathanakos, Georgios [2 ]
Kitsouli, Aikaterini [3 ]
Troupis, Theodoros [4 ]
Barbouti, Alexandra [3 ]
Vlachos, Konstantinos [1 ]
Kanavaros, Panagiotis [3 ]
Kitsoulis, Panagiotis [3 ,5 ]
机构
[1] Univ Hosp Ioannina, Dept Surg, Ioannina, Greece
[2] Univ Hosp Ioannina, Intens Care Unit, Ioannina, Greece
[3] Univ Ioannina, Anat Histol Embryol, Ioannina, Greece
[4] Natl & Kapodistrian Univ Athens, Med Sch, Dept Anat, Athens, Greece
[5] Univ Ioannina, Orthopaed, Ioannina, Greece
来源
IN VIVO | 2021年 / 35卷 / 02期
关键词
Osteochondroma; exostosis; HME; imaging; chondrosarcoma; review; HEREDITARY MULTIPLE EXOSTOSES; SOLITARY OSTEOCHONDROMA; CARTILAGINOUS TUMORS; BONE-TUMORS; SPINAL-CORD; SYMPTOMATIC OSTEOCHONDROMAS; HETEROTOPIC OSSIFICATION; COMPRESSIVE MYELOPATHY; SURGICAL-TREATMENT; HEPARAN-SULFATE;
D O I
10.21873/invivo.12308
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Osteochondroma, the most common benign bone tumor, is a projection on the external surface of the bone, which can be sessile or pedunculated. 85% of osteochondromas present as solitary lesions, while 15% occur in the context of hereditary multiple exostoses (HME), a genetic disorder that is inherited in an autosomal dominant manner. Although often asymptomatic, symptoms may eventuate from compression of adjacent vessels or nerves, fractures, osseous deformities, bursa formation, or malignant transformation. Cartilage cap thickness >2 cm in adults or >3 cm in children as well as new onset of pain or growth, or rapid growth of the lesion, especially after the closure of the growth plate, might reflect cancerous transformation. Surgical resection is indicated for symptomatic lesions, complications, cosmetic reasons or malignant transformation. Excision of the tumor with free margin is the treatment of choice. Local recurrence is less than 2% if complete resection is achieved.
引用
收藏
页码:681 / 691
页数:11
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