Lymphocyte commitment during embryonic development, in the mouse

被引：31

作者：

Douagi, I ^{[1
]}

Vieira, P ^{[1
]}

Cumano, A ^{[1
]}

机构：

[1] Inst Pasteur, URA CNRS 1961, Unite Dev Lymphoctes, F-75724 Paris 15, France

来源：

SEMINARS IN IMMUNOLOGY | 2002年 / 14卷 / 06期

关键词：

bone marrow; commitment; fetal liver; hematopoiesis; lymphocytes;

D O I：

10.1016/S1044532302000702

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multipolent hematopoietic stem cells (HSC) differentiate into mature cells in the fetal liver (FL) during embryonic development, and in the bone marrow (BM) in adult animals. Multilineage differentiation is accomplished by the stepwise commitment of stem cells that sequentially loose differentiation potential. The characterization of the intermediate lymphoid precursors isolated from both hematopoietic sites suggests that, in FL, their potential of differentiation as well as their growth factor requirements are apparently less strict than in the BM. This could be the result of different commitment strategies at those sites: stochastic in the FL and instructive in the BM.

引用

页码：361 / 369

页数：9

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