INFLUENCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) ON GASTROPROTECTION IN STRESS-INDUCED GASTRIC MUCOSAL ULCERS IN RATS

被引：4

作者：

Wozniak-Holecka, J. ^{[1
]}

Josko, J. ^{[2
,3
]}

Tyrpien, M. ^{[2
,3
]}

Kasperczyk, J. ^{[2
,3
]}

Steplewska, K. ^{[4
]}

Holecki, T. ^{[5
]}

机构：

[1] Med Univ Silesia, Chair Publ Hlth, PL-41902 Bytom, Poland

[2] Med Univ Silesia, Chair Environm Med & Epidemiol, Zabrze, Poland

[3] Med Univ Silesia, Dept Environm Med & Epidemiol, Zabrze, Poland

[4] Med Univ Silesia, Chair Clin Pathomorphol, Zabrze, Poland

[5] Med Univ Silesia, Chair Hlth Econ, PL-41902 Bytom, Poland

来源：

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 2009年 / 31卷 / 08期

关键词：

Vascular endothelial growth factor; Gastroprotection; Angiogenesis; Stress-induced gastric ulceration; GENE-THERAPY; ACTIVATION; PROSTAGLANDINS; ANGIOGENESIS; MECHANISMS; EXPRESSION; PROTEIN;

D O I：

10.1358/mf.2009.31.8.1419716

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the process of evolution a number of complicated mechanisms hove developed to protect the gastric mucous membrane, e.g., angiogenesis and stimulation of mucosal growth. The aim of this study was to determine the role of vascular endothelial growth factor (VEGF) administered intraperitoneally in the gastroprotective response to stress-induced acute gastric ulcers in rots. A dramatic increase in the number of blood vessels was observed when VEGF was injected 24 h before stress exposure. Gastric secretion, depth of ulceration and ulceration index decreased significantly after VEGF application. The results demonstrate the gastroprotective effect of VEGF on stress-induced ulceration.

引用

页码：523 / 531

页数：9

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