Dynamic evaluation of circulating tumour cells in patients with advanced gastric and oesogastric junction adenocarcinoma: Prognostic value and early assessment of therapeutic effects

被引：47

作者：

Pernot, Simon ^{[1
,2
]}

Badoual, Cecile ^{[1
,3
]}

Terme, Magali ^{[1
]}

Castan, Florence ^{[4
]}

Cazes, Aurelie ^{[3
]}

Bouche, Olivier ^{[5
]}

Bennouna, Jaafar ^{[6
]}

Francois, Eric ^{[7
]}

Ghiringhelli, Francois ^{[8
]}

De La Fouchardiere, Christelle ^{[9
]}

Samalin, Emmanuelle ^{[10
]}

Bachet, Jean Baptiste ^{[11
]}

Borg, Christophe ^{[12
]}

Ducreux, Michel ^{[13
]}

Marcheteau, Elie ^{[1
]}

Stanbury, Trevor ^{[14
]}

Gourgou, Sophie ^{[4
]}

Malka, David ^{[13
]}

Taieb, Julien ^{[1
,2
,3
]}

机构：

[1] Paris Descartes Univ, Sorbonne Paris Cite, INSERM U970, PARCC Paris Cardiovasc Res Ctr, Paris, France

[2] Paris Descartes Univ, Hop Europeen Georges Pompidou, AP HP, Sorbonne Paris Cite,Dept GI Oncol, Paris, France

[3] Paris Descartes Univ, Hop Europeen Georges Pompidou, AP HP, Sorbonne Paris Cite,Dept Pathol, Paris, France

[4] Montpellier Canc Inst, ICM, CTD INCa, Biostat Unit, Montpellier, France

[5] CHU Robert Debre, Reims, France

[6] Inst Cancerol Ouest, Site Rene Gauducheau, St Herblain, France

[7] Ctr Antoine Lacassagne, Nice, France

[8] Ctr Georges Francois Leclerc, Dijon, France

[9] Ctr Leon Berard, Lyon, France

[10] CRLC Val dAurelle, Montpellier, France

[11] Hop Pitie Salpetriere Hosp, Paris, France

[12] CHU Minjoz, Med Oncol Unit, Besancon, France

[13] Univ Paris Saclay, Gustave Roussy, Dept Med Oncol, F-94805 Villejuif, France

[14] UNICANCER, Paris, France

来源：

EUROPEAN JOURNAL OF CANCER | 2017年 / 79卷

关键词：

Circulating tumour cells; Stomach neoplasms; Prognosis; Biomarkers; Clinical trial; PROGRESSION-FREE; PHASE-III; CANCER; SURVIVAL; FLUOROURACIL; CAPECITABINE; MULTICENTER; CISPLATIN; DOCETAXEL;

D O I：

10.1016/j.ejca.2017.03.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The identification of dynamic biomarkers in advanced gastric and oesogastric junction adenocarcinoma (GOA) could help to tailor strategies for each patient. Enumeration of circulating tumour cells (CTCs) is approved by the US Food and Drug Administration in breast, colon and prostate cancer but is not in advanced GOA. Our study aims to establish the optimal threshold and the clinical significance of CTC count in advanced GOA before and during treatment. Methods: One hundred six patients with untreated advanced GOA were included in the ancillary study of the PRODIGE 17-ACCORD 20 trial. CTCs were detected in the peripheral blood using the CellSearch system on day 0 (D0) and day 28 (D28). The prognostic value of CTCs at D0 and D28 was analysed by testing several thresholds. Results: At baseline, median CTC count was 1 (range, 0-415). While CTCs >= 1, 2 or 3 at D0 were all significantly associated with worse overall survival (OS) and progression-free survival (PFS), CTCs >2 were the optimal threshold, on D0 or D28. CTCs >2 at D28 were also predictive of disease control. Taking into account both D0 and D28 CTC count defined 3 groups (low/low, high/low and low-high/high) with significantly different PFS (p = 0.0002) and OS (p = 0.003). Conclusion: Quantification of CTCs at baseline and during treatment may be a useful prognostic tool in advanced GOA, as it is associated with worse PFS and OS. A threshold >= 2 CTCs seems to have the best discriminant value. Change in CTC count between baseline and D28 could help to tailor treatment to each individual patient. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：15 / 22

页数：8

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