Ligand-Enabled Gold-Catalyzed C(sp2)-S Cross-Coupling Reactions

被引：39
|
作者：
Tathe, Akash G. [1 ]
Patil, Nitin T. [1 ]
机构：
[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal 462066, India
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 24期
关键词：
VINYL SULFONES; BOND FORMATION; C-S;
D O I：
10.1021/acs.orglett.2c01692
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report C(sp(2))-S cross-coupling reactions of aryl iodides and arylsulfonyl hydrazides under ligand-enabled, Au(I)/Au(III) redox catalysis. This strategy operates under mild reaction conditions, requires no prefunctionalized aryl coupling partner, and works across several aryl iodides. The utility of this protocol is highlighted through the synthesis of various medicinally relevant biaryl sulfones. The reaction mechanism is supported with control experiments, mass spectrometry, and NMR studies.
引用
收藏
页码：4459 / 4463
页数：5
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