Clastogenicity of carbazole in mouse bone marrow cells in vivo

被引：11

作者：

Jha, AA ^{[1
]}

Singh, AC ^{[1
]}

Bharti, MK ^{[1
]}

机构：

[1] Samastipur Coll, Genet Toxicol Lab, Dept Bot & Biotechnol, Samastipur 848134, India

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2002年 / 521卷 / 1-2期

关键词：

clastogenicity; carbazole; mitofic index; chromosomal aberration; bone marrow cells;

D O I：

10.1016/S1383-5718(02)00210-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Clastogenicity of carbazole was evaluated by employing mouse in vivo chromosomal aberration (CA) test. Carbazole administered intraperitoneally (i.p.) at the rate of 25, 50, 100, 150 and 200 mg/kg b.w. to Swiss albino mice in vivo resulted in mitotic depression and induction of chromosomal aberrations. Dose related decrease in mitotic index (MI) and increase in the frequencies of chromosomal aberrations per cell (CAs/cell) and percent abnormal cells were recorded in bone marrow cells. However, statistically significant reduction in MI and increase in CAs/cell and percent abnormal cells were found only for the two higher doses. The results obtained indicate that carbazole or its metabolite, if any, is moderately clastogenic in the bone marrow cells of Swiss albino mice. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：11 / 17

页数：7

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