Genetics of insulin resistance in polycystic ovary syndrome

被引:16
作者
Obermayer-Pietsch, Barbara [1 ]
Trummer, Christian [1 ]
Schwetz, Verena [1 ]
Schweighofer, Natascha [1 ]
Pieber, Thomas [1 ]
机构
[1] Med Univ Graz, Dept Internal Med, Div Endocrinol & Metab, Auenbruggerpl 15, A-8036 Graz, Austria
关键词
androgens; genetics; insulin resistance; polycystic ovary syndrome; type 2 diabetes mellitus; ANDROGEN EXCESS; ASSOCIATION; WOMEN; POLYMORPHISM; METABOLISM; PARAMETERS; VARIANTS; COHORT; PCOS;
D O I
10.1097/MCO.0000000000000190
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Polycystic ovary syndrome (PCOS) is a very common endocrine disease in women all over the world. A variety of symptoms such as hirsutism and hyperandrogenism, irregular menstrual cycles and anovulatory infertility together with metabolic dysfunction, insulin resistance, and type 2 diabetes mellitus in lean and obese individuals and the development of consecutive diseases are key problems in this heterogeneous syndrome. Recent findings Disease-modifying and potentially disease-causing candidate genes are described. A number of genetic associations have been investigated, whereby genes related to normal-weight insulin resistance and chronic inflammation are of central interest for PCOS pathomechanisms. New insights in the pharmacogenetics of PCOS might help to individualize therapeutic options. Summary Enormous progress has been made in the genetics of insulin resistance in PCOS. However, because of the individual heterogeneity of PCOS and the lack of evident functional studies, the syndrome is only partly understood to date. Large studies on selected phenotypes and therapy aspects are ongoing.
引用
收藏
页码:401 / 406
页数:6
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