Systematic Mapping of Genetic Interaction Networks

被引：197

作者：

Dixon, Scott J. ^{[1
,2
]}

Costanzo, Michael ^{[1
]}

Baryshnikova, Anastasia ^{[1
]}

Andrews, Brenda ^{[1
]}

Boone, Charles ^{[1
]}

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 1A7, Canada

[2] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

ANNUAL REVIEW OF GENETICS | 2009年 / 43卷

基金：

加拿大健康研究院;

关键词：

genetic interaction; network; synthetic lethal; Saccharomyces cerevisiae; epistasts; PROTEIN-PROTEIN INTERACTIONS; MODE-OF-ACTION; SYNTHETIC LETHAL; CAENORHABDITIS-ELEGANS; HIGH-THROUGHPUT; FUNCTIONAL-ANALYSIS; DELETERIOUS MUTATIONS; BIOACTIVE COMPOUNDS; SCREENS IDENTIFY; RNAI LIBRARY;

D O I：

10.1146/annurev.genet.39.073003.114751

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic interactions influencing a phenotype of interest call be identified systematically using libraries of genetic tools that perturb biological systems in a defined manner. Systematic screens conducted in the yeast Saccharomyces cerevisiae have identified thousands of genetic interactions land provided insight into the global structure of biological networks. Techniques enabling systematic genetic interaction mapping have been extended to other single-celled organisms, the bacteria Escherichia coli and the yeast Schizosaccharomyces pombe, opening the way to comparative investigations of interaction networks. Genetic interaction screens in Caenorhabditis elegans, Drosophila melanogaster and mammalian models are helping to improve our understanding of metazoan-specific signaling pathways. together, our emerging knowledge of the genetic wiring diagrams of eukaryotic and prokaryotic cells is providing a new understanding of the relationship between genotype and phenotype.

引用

页码：601 / 625

页数：25

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