Reductive amination with zinc borohydride. Efficient, safe route to fluorinated benzylamines

被引：53

作者：

Bhattacharyya, S ^{[1
]}

Chatterjee, A ^{[1
]}

Williamson, JS ^{[1
]}

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,DEPT MED CHEM,UNIVERSITY,MS 38677

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 24期

关键词：

D O I：

10.1080/00397919708005050

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorinated benzylamines are synthesized in high yields by reductive alkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptable to multigram-scale preparations.

引用

页码：4265 / 4274

页数：10

共 68 条

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