Reductive amination with zinc borohydride. Efficient, safe route to fluorinated benzylamines

被引：53
作者：
Bhattacharyya, S [1 ]
Chatterjee, A [1 ]
Williamson, JS [1 ]
机构：
[1] UNIV MISSISSIPPI,SCH PHARM,DEPT MED CHEM,UNIVERSITY,MS 38677
来源：
SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 24期
关键词：
D O I：
10.1080/00397919708005050
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fluorinated benzylamines are synthesized in high yields by reductive alkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptable to multigram-scale preparations.
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页码：4265 / 4274
页数：10
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