GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: A time analysis

被引：68

作者：

Fitzgerald, Paul B. ^{[1
]}

Maller, Jerome J. ^{[1
]}

Hoy, Kate ^{[1
]}

Farzan, Faranak ^{[2
]}

Daskalakis, Zafiris J. ^{[2
]}

机构：

[1] Alfred & Monash Univ, Sch Psychol Psychiat & Psychol Med, Monash Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia

[2] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada

来源：

CLINICAL NEUROPHYSIOLOGY | 2009年 / 120卷 / 09期

基金：

英国医学研究理事会;

关键词：

Cortical inhibition; Motor cortex; Parietal cortex; Dorsolateral prefrontal cortex; GABA; Electroencephalography; Transcranial magnetic stimulation; Phase; TRANSCRANIAL MAGNETIC STIMULATION; DORSOLATERAL PREFRONTAL CORTEX; SILENT PERIOD; EXCITABILITY; RESPONSES; RAT;

D O I：

10.1016/j.clinph.2009.06.019

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The induction of long interval cortical inhibition (LICI) in motor cortex with paired pulse transcranial magnetic stimulation (ppTMS) is an established paradigm for the assessment of cortical inhibition, proposed to be related to GABA(B) receptor inhibitory neurotransmission. This study aimed to further evaluate recent methods of the assessment of LICI in non motor regions with ppTMS and electroencephalography (EEG). Methods: ppTMS was applied using a single coil to the motor and dorsolateral prefrontal cortex (DLPFC) in 14 healthy subjects, and in the parietal lobe in 5 of those subjects. Results: In the motor cortex, LICI resulted in significant suppression in mean cortical evoked activity on EEG between 75 and 250 ms following delivery of the test stimulus. Maximal inhibition was seen from 50 to 250 ms in DLPFC, and between 50 and 175 ms in the parietal lobe. Conclusions: ppTMS may be used to produce LICI in several cortical regions with a time course similar to known GABA(B) activity. Significance: ppTMS induction of LICI can be recorded by combining TMS with EEG and seems to relate to GABAB activity. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：1706 / 1710

页数：5

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