Tumor necrosis factor receptor associated periodic syndrome (TRAPS).: Report of two cases

Tumor Necrosis Factor Receptor Associated Periodic syndrome (TRAPS) is an autoinflammatory disorder associated to a mutation of the Tumor Necrosis Factor Receptor 1 (TNFR1) whose clinical presentation consists on recurrent episodes of prolonged fever; abdominal pain, myalgias, migratory cutaneous erythema, conjunctivitis or periorbitary edema. The diagnosis is confirmed by genetic analysis of the TNFR1 gene. Its main complication is amyloidosis and the treatment is based on the rise of corticosteroids or anti-TAT antibodies. We report a 17 year old male and 23 year old female with the syndrome. Both cases bad heterozygous mutations of the TNFR1 gene, C30R in the first case and T50M in the second case.