Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system

被引：138
作者：
Lili Cheng
Xiaoyu Wu
Yixin Lu
机构：
[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore
[2] Natl Univ Singapore, Med Chem Program, Off Life Sci, Singapore 117543, Singapore
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 07期
关键词：
D O I：
10.1039/b701579h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct three-component Mannich reactions of O-benzyl hydroxyacetone with p-anisidine and aromatic or aliphatic aldehydes in the presence of an L-threonine-derived catalyst afforded anti-1,2-amino alcohols in good-to-excellent yields and with enantioselectivities of up to 97%. This study is the first demonstration that direct three-component Mannich reactions can be promoted by a primary amino acid in water.
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收藏
页码：1018 / 1020
页数：3
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