Eye vessels saved by rescuing their pericyte partners

被引：13

作者：

Antonetti, David ^{[1
]}

机构：

[1] Penn State Coll Med, Dept Cellular & Mol Physiol & Ophthalmol, Hershey, PA USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 11期

关键词：

ENDOTHELIAL GROWTH-FACTOR; PROTEIN-KINASE-C; DIABETIC-RETINOPATHY; OCCLUDIN PHOSPHORYLATION; PERMEABILITY; ACTIVATION;

D O I：

10.1038/nm1109-1248

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

High blood sugar can lead to diabetic retinopathy and subsequent blindness. Glucose is now found to quench a growth factor that keeps pericytes alive. Without these key support cells, the retinal vasculature degenerates (pages 1298-1306).

引用

页码：1248 / 1249

页数：3

共 11 条

[1] Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy [J].

Abraham, Prema ;

Adelman, Ron A. ;

Alfaro, Daniel Virgil, III ;

Anand, Rajiv ;

Antoszyk, Andrew ;

Bergsma, Donald ;

Hartnett, Mary Elizabeth ;

Brucker, Alexander J. ;

Carr, Tyree ;

Casey, Raynor C. ;

Rubino, John ;

Chandler, Thomas W. ;

Charles, Steven ;

Chaudhry, Nauman ;

Combs, James ;

Doft, Bernard ;

Young, Lucy H. Y. ;

Drouilhet, John H. ;

Dugel, Pravin U. ;

Feman, Stephen S. ;

Finkelstein, Daniel ;

Foster, Robert E. ;

Petersen, Michael R. ;

Fox, Gregory ;

Garretson, Bruce ;

Gieser, Jon P. ;

Gentile, Ronald C. ;

Giovinazzo, Vincent ;

Glazer, Louis ;

Goodart, Roy A. ;

Gottlieb, Justin ;

Greven, Craig ;

Grizzard, William S. ;

Hainsworth, Dean P. ;

Halperin, Lawrence ;

Heier, Jeffrey S. ;

Jackson, William ;

Kubacki, Joseph J. ;

Kanter, Eric D. ;

Keyser, Bruce ;

Kingsley, Ronald ;

Ko, Paula ;

Kokame, Gregg T. ;

Kuppermann, Baruch ;

Lambert, H. Michael ;

Lewis, Hilel ;

Lewis, Richard Alan ;

Marcus, Dennis ;

Nussbaum, Julian ;

Maturi, Raj K. .

OPHTHALMOLOGY, 2006, 113 (12) :2221-2230

[2] VASCULAR ENDOTHELIAL GROWTH-FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC-RETINOPATHY AND OTHER RETINAL DISORDERS [J].

AIELLO, LP ;

AVERY, RL ;

ARRIGG, PG ;

KEYT, BA ;

JAMPEL, HD ;

SHAH, ST ;

PASQUALE, LR ;

THIEME, H ;

IWAMOTO, MA ;

PARK, JE ;

NGUYEN, HV ;

AIELLO, LM ;

FERRARA, N ;

KING, GL .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (22) :1480-1487

[3] RETINAL VASCULAR PATTERNS .4. DIABETIC RETINOPATHY [J].

COGAN, DG ;

KUWABARA, T ;

TOUSSAINT, D .

ARCHIVES OF OPHTHALMOLOGY, 1961, 66 (03) :366-&

[4] The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis [J].

Dubois, Marie-Julie ;

Bergeron, Sébastien ;

Kim, Hyo-Jeong ;

Dombrowski, Luce ;

Perreault, Mylène ;

Fournès, Bénédicte ;

Faure, Robert ;

Olivier, Martin ;

Beauchemin, Nicole ;

Shulman, Gerald I. ;

Siminovitch, Katherine A. ;

Kim, Jason K. ;

Marette, André .

NATURE MEDICINE, 2006, 12 (05) :549-556

[5] Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy [J].

Enge, M ;

Bjarnegård, M ;

Gerhardt, H ;

Gustafsson, E ;

Kalén, M ;

Asker, N ;

Hammes, HP ;

Shani, M ;

Fässler, R ;

Betsholtz, C .

EMBO JOURNAL, 2002, 21 (16) :4307-4316

[6] Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy [J].

Geraldes, Pedro ;

Hiraoka-Yamamoto, Junko ;

Matsumoto, Motonobu ;

Clermont, Allen ;

Leitges, Michael ;

Marette, Andre ;

Aiello, Lloyd P. ;

Kern, Timothy S. ;

King, George L. .

NATURE MEDICINE, 2009, 15 (11) :1298-U133

[7] VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability [J].

Harhaj, Nicole S. ;

Felinski, Edward A. ;

Wolpert, Ellen B. ;

Sundstrom, Jeffrey M. ;

Gardner, Thomas W. ;

Antonetti, David A. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (11) :5106-5115

[8] Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor [J].

Ishii, H ;

Jirousek, MR ;

Koya, D ;

Takagi, C ;

Xia, P ;

Clermont, A ;

Bursell, SE ;

Kern, TS ;

Ballas, LM ;

Heath, WF ;

Stramm, LE ;

Feener, EP ;

King, GL .

SCIENCE, 1996, 272 (5262) :728-731

[9]

Klein R, 2008, CONTEMP DIABETES, P67, DOI 10.1007/978-1-59745-563-3_3

[10] Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability [J].

Murakami, Tomoaki ;

Felinski, Edward A. ;

Antonetti, David A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (31) :21036-21046

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