Protocatechuic Acid Inhibits Rat Pheochromocytoma Cell Damage Induced by a Dopaminergic Neurotoxin

被引：22

作者：

Zhang, Hong-Ning ^{[1
,2
]}

An, Chun-Na ^{[1
,2
]}

Xu, Man ^{[3
]}

Guo, De-An ^{[3
]}

Li, Min ^{[1
]}

Pu, Xiao-Ping ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Peking Univ, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China

[3] Peking Univ, Dept Nat Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2009年 / 32卷 / 11期

关键词：

protocatechuic acid; neuroprotection; rat pheochromocytoma cell; 1-methyl-4-phenylpyridinium ion; alpha-synuclein; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; PC12; CELLS; BRAIN; APOPTOSIS; ANALOGS;

D O I：

10.1248/bpb.32.1866

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) with the presence of alpha-synuclein inclusions termed Lewy bodies. The aggregation of alpha-synuclein into oligomeric species affects neuronal viability, having a causal role in the development of PD. The neuroprotective effects of protocatechuic acid (PAc) have been reported. However. the effects of PAc on tyrosine hydroxylase (TH) and alpha-synuclein in rat pheochromocytoma (PC12) cells treated with 1-methyl-4-phenylpyridinium ion (MPP+) remains unclear. In this study, we demonstrated that PAc inhibited the cytotoxicity, apoptotic morphology, reduction of TH expression and abnormal oligomeration of alpha-synuclein in PC12 cells treated with MPP+. Taken together, our results indicate that the neuroprotective effects of PAc on PC12 cells treated with MPP+ is related to the inhibition of the oligomerization of alpha-synuclein.

引用

页码：1866 / 1869

页数：4

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