Maternal exposure to phenanthrene during gestation disturbs glucose homeostasis in adult mouse offspring

被引：15

作者：

Guo, Jiaojiao ^{[1
]}

Huang, Jie ^{[1
]}

Wang, Qian ^{[2
]}

Fang, Lu ^{[1
]}

Zhang, Shenli ^{[1
]}

Li, Bingshui ^{[1
]}

Lv, Liangju ^{[1
]}

Chen, Meng ^{[2
]}

Wang, Chonggang ^{[1
]}

机构：

[1] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Fujian, Peoples R China

[2] Xiamen Univ, Coll Environm & Ecol, Xiamen 361102, Fujian, Peoples R China

来源：

CHEMOSPHERE | 2021年 / 270卷

基金：

中国国家自然科学基金;

关键词：

In utero exposure; Glucose homeostasis; Polycyclic aromatic hydrocarbons; Insulin resistance; DNA methylation;

D O I：

10.1016/j.chemosphere.2020.128635

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Epidemiological studies have indicated that polycyclic aromatic hydrocarbons were related to diabetes and insulin resistance. However, studies in mammals on the development of diabetes caused by polycyclic aromatic hydrocarbons are lacking. Pregnant mice were orally exposed to phenanthrene (0, 60 and 600 mu g kg(-1) body weight) once every 3 days during gestation. In adult mouse offspring, in-utero phenanthrene exposure caused glucose intolerance and decreased insulin levels in females, while caused elevated fasting blood glucose and insulin levels in males. Serum resistin and interleukin-6 levels were elevated in offspring of both sexes. Serum adiponectin levels were decreased in females but increased in males. The insulin receptor signals were upregulated in the liver and downregulated in the skeletal muscle of F1 females, while they were inhibited in both tissues of F1 males. The visceral fat weight and body weight of the treated mice were not increased, suggesting that phenanthrene is not an obesogen, which is supported by the nonsignificant alteration in ppar gamma transcription in visceral adipose tissue. The transcription of retn in visceral adipose tissue was upregulated in both sexes, and that of adipoq was downregulated in females but upregulated in males, which were matched with the promoter methylation levels of these genes. The results indicated that phenanthrene exposure during gestation could disturb adipocytokine levels via epigenetic modification in adult offspring, and further influence glucose metabolism. These results might be helpful for understanding nonobesogenic pollutant-induced insulin resistance and preventing against diabetes without obesity. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：11

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