Titanocene-catalyzed reduction of lactones to lactols

被引：64

作者：

Verdaguer, X ^{[1
]}

Hansen, MC ^{[1
]}

Berk, SC ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 24期

关键词：

D O I：

10.1021/jo971560s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the conversion of lactones to lactols is described. The hydrosilylation to lactols is carried out via air-stable titanocene difluoride or a titanocene diphenoxide precatalyst using inexpensive polymethylhydrosiloxane (PMHS) as the stoichiometric reductant. These procedures have been demonstrated with a variety of substrates and proceed in good to excellent yield.

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页码：8522 / 8528

页数：7

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