Lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney: Effect of treatment with angiotensin convertase inhibitors

被引：0

作者：

Kedziora-Kornatowska, KZ

Luciak, M

Paszkowski, J

机构：

[1] Mil Med Univ, Dept Internal Med, PL-90647 Lodz, Poland

[2] Mil Med Univ, Inst Logist, Lab Appl Informat, Lodz, Poland

来源：

IUBMB LIFE | 2000年 / 49卷 / 04期

关键词：

captopril; catalase; diabetes; enalapril; lipid peroxidation; oxidative stress; superoxide dismutase;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of the angiotensin convertase inhibitors captopril (CAP) and enalapril (ENA) on the malondialdehyde (MDA) content and the activities of superoxide dismutase (SOD) and catalase in the kidneys of rats with streptozotocin-induced diabetes were studied, Induction of diabetes resulted in an increase of MDA concentration and progressive decreases of SOD and catalase activities after 6 and 12 weeks. CAP and ENA administration did not affect body weight changes or blood glucose and HbA(1c) contents in diabetic rats but decreased albuminuria and kidney weight increase, attenuated lipid peroxidation, and prevented the decreases in SOD and catalase activities. These results confirm the oxidative stress in streptozotocin-induced experimental diabetes and point to the beneficial antioxidant effects of angiotensin convertase inhibitors.

引用

页码：303 / 307

页数：5

共 24 条

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