Prostate Cancer Prevention: Concepts and Clinical Trials

被引：9

作者：

Hamilton, Zachary ^{[1
]}

Parsons, J. Kellogg ^{[1
]}

机构：

[1] UC San Diego Hlth Syst, Dept Urol, Moores Comprehens Canc Ctr, 3855 Hlth Sci Dr,Mail Code 0987, La Jolla, CA 93093 USA

来源：

CURRENT UROLOGY REPORTS | 2016年 / 17卷 / 04期

关键词：

Prostate cancer; 5-Alpha reductase inhibitors; Immunotherapy; VITAMIN-E; LARGE COHORT; 5-ALPHA-REDUCTASE INHIBITORS; RANDOMIZED PROSTATE; SIPULEUCEL-T; DOUBLE-BLIND; RISK; MEN; MORTALITY; DUTASTERIDE;

D O I：

10.1007/s11934-016-0587-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Prevention is an important treatment strategy for diminishing prostate cancer morbidity and mortality and is applicable to both early-and late-stage disease. There are three basic classifications of cancer prevention: primary (prevention of incident disease), secondary (identification and treatment of preclinical disease), and tertiary (prevention of progression or recurrence). Based on level I evidence, 5-alpha reductase inhibitors (5-ARIs) should be considered in selected men to prevent incident prostate cancer. Level I evidence also supports the consideration of dutasteride, a 5-ARI, for tertiary prevention in active surveillance and biochemical recurrence patients. Vitamins and supplements, including selenium or vitamin E, have not been proven in clinical trials to prevent prostate cancer and in the case of Vitamin E has been found to increase the risk of incident prostate cancer. Ongoing and future trials may further elucidate the role of diet and immunotherapy for prevention of prostate cancer.

引用

页数：9

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