Colorimetric detection of sodium ion in serum based on the G-quadruplex conformation related DNAzyme activity

被引：33

作者：

Sun, Hongxia ^{[1
]}

Chen, Hongbo ^{[1
,2
]}

Zhang, Xiufeng ^{[2
]}

Liu, Yan ^{[1
]}

Guan, Aijiao ^{[1
]}

Li, Qian ^{[1
]}

Yang, Qianfan ^{[1
]}

Shi, Yunhua ^{[1
,3
]}

Xu, Shujuan ^{[1
,3
]}

Tang, Yalin ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Natl Lab Mol Sci,Ctr Mol Sci, Beijing 100190, Peoples R China

[2] N China Univ Sci & Technol, Coll Chem Engn, Tangshan 063009, Peoples R China

[3] Grad Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2016年 / 912卷

基金：

中国国家自然科学基金;

关键词：

G-quadruplex DNAzyme; Na+ detection; Colorimetric; Serum; HEMIN/G-QUADRUPLEX; FLUORESCENT-PROBE; SENSOR; DNA;

D O I：

10.1016/j.aca.2016.01.041

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

There has been a big challenge in developing the Na+ sensor that can be practically used in the physiological system with the interference of large amounts of K+. In this research, a novel Na+ sensor has been designed based on the G-quadruplex-conformation related DNAzyme activity. The sensor exhibits high selectivity and sensitivity with the detection limit of 0.6 mu M, which enables the sensor to be practically used in determination of the Na+ level in serum. The research not only provides a simple Na+ sensor but also opens a new way for developing the detection technology of Na+. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：133 / 138

页数：6

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