Lack of therapeutic efficacy of an antibody to α4β7 SIVmac251-infected rhesus macaques

被引：25

作者：

Abbink, Peter ^{[1
]}

Mercado, Noe B. ^{[1
]}

Nkolola, Joseph P. ^{[1
]}

Peterson, Rebecca L. ^{[1
]}

Tuyishime, Hubert ^{[1
]}

McMahan, Katherine ^{[1
]}

Moseley, Edward T. ^{[1
]}

Borducchi, Erica N. ^{[1
]}

Chandrashekar, Abishek ^{[1
]}

Bondzie, Esther A. ^{[1
]}

Agarwal, Arshi ^{[1
]}

Belli, Aaron J. ^{[2
]}

Reimann, Keith A. ^{[2
]}

Keele, Brandon F. ^{[3
]}

Geleziunas, Romas ^{[4
]}

Lewis, Mark G. ^{[5
]}

Barouch, Dan H. ^{[1
,6
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] Univ Massachusetts, Med Sch, MassBiol, Boston, MA 02126 USA

[3] Frederick Natl Lab, AIDS & Canc Virus Program, Frederick, MD 21702 USA

[4] Gilead Sci, Foster City, CA 94404 USA

[5] Bioqual, Rockville, MD 20852 USA

[6] Ragon Inst Massachusetts Gen Hosp Massachusetts I, Cambridge, MA 02139 USA

来源：

SCIENCE | 2019年 / 365卷 / 6457期

基金：

美国国家卫生研究院;

关键词：

REPLICATION;

D O I：

10.1126/science.aaw8562

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sustained virologic control of human immunodeficiency virus type 1 (HIV-1) infection after discontinuation of antiretroviral therapy (ART) is a major goal of the HIV-1 cure field. A recent study reported that administration of an antibody against alpha(4)beta(7) induced durable virologic control after ART discontinuation in 100% of rhesus macaques infected with an attenuated strain of simian immunodeficiency virus (SIV) containing a stop codon in nef. We performed similar studies in 50 rhesus macaques infected with wild-type, pathogenic SIVmac251. In animals that initiated ARTduring either acute or chronic infection, anti-alpha(4)beta(7) antibody infusion had no detectable effect on the viral reservoir or viral rebound after ART discontinuation. These data demonstrate that anti-alpha(4)beta(7) antibody administration did not provide therapeutic efficacy in the model of pathogenic SIVmac251 infection of rhesus macaques.

引用

页码：1029 / +

页数：27

共 18 条

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