Chemosensors for the marine toxin saxitoxin

被引：57
作者：
Gawley, RE
Pinet, S
Cardona, CM
Datta, PK
Ren, T
Guida, WC
Nydick, J
Leblanc, RM
机构：
[1] Univ Miami, Dept Chem, Coral Gables, FL 33124 USA
[2] Univ Miami, NIEHS, Marine & Freshwater Biomed Sci Ctr, Coral Gables, FL 33124 USA
[3] Eckerd Coll, Dept Chem, Petersburg, FL 33711 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 45期
关键词：
D O I：
10.1021/ja027507p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Eleven anthracylmethyl crown ethers have been synthesized and evaluated as fluorescence sensors for the marine toxin saxitoxin. Fluorescence enhancement data are consistent with a 1:1 binding complex for all crowns. The binding constants are in the range of 10(4) M-1 in ammonium phosphate buffer (pH 7.1) in 80% ethanol solvent. Selectivity for sensing saxitoxin versus several organic analytes has been demonstrated for the first time. Possible modes of binding are presented, and relevance to saxitoxin monitoring programs are discussed.
引用
收藏
页码：13448 / 13453
页数：6
相关论文
共 59 条
[1]  
AYRES PA, 1978, PARALYTIC SHELLFISH
[2]  
Baden D. G., 1995, HDB CLIN NEUROLOGY 2, V21, P141
[3]   SIMULTANEOUS DETERMINATION OF STOICHIOMETRY, DEGREE OF CONDENSATION AND STABILITY CONSTANT - A GENERALIZATION OF THE MOLAR-RATIO METHOD [J].
BELTRANPORTER, A ;
BELTRANPORTER, D ;
CERVILLA, A ;
RAMIREZ, JA .
TALANTA, 1983, 30 (02) :124-126
[4]  
BISSELL RA, 1993, TOP CURR CHEM, V168, P223
[5]   LUMINESCENCE AND CHARGE-TRANSFER .2. AMINOMETHYL ANTHRACENE-DERIVATIVES AS FLUORESCENT PET (PHOTOINDUCED ELECTRON-TRANSFER) SENSORS FOR PROTONS [J].
BISSELL, RA ;
CALLE, E ;
DE SILVA, AP ;
DESILVA, SA ;
GUNARATNE, HQN ;
HABIBJIWAN, JL ;
PEIRIS, SLA ;
RUPASINGHE, RADD ;
SAMARASINGHE, TKSD ;
SANDANAYAKE, KRAS ;
SOUMILLION, JP .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1992, (09) :1559-1564
[6]   STRUCTURE OF A CRYSTALLINE DERIVATIVE OF SAXITOXIN - STRUCTURE OF SAXITOXIN [J].
BORDNER, J ;
THIESSEN, WE ;
BATES, HA ;
RAPOPORT, H .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (21) :6008-6012
[7]   QUANTITATIVE-ANALYSIS OF CONTINUOUS-VARIATION PLOTS WITH A COMPARISON OF SEVERAL METHODS - SPECTROPHOTOMETRIC STUDY OF ORGANIC AND INORGANIC 1-1 STOICHIOMETRY COMPLEXES [J].
BRUNEAU, E ;
LAVABRE, D ;
LEVY, G ;
MICHEAU, JC .
JOURNAL OF CHEMICAL EDUCATION, 1992, 69 (10) :833-837
[8]  
Cheun BS, 1998, AGRO FOOD IND HI TEC, V9, P36
[9]  
Cheun BS, 1998, J NAT TOXINS, V7, P109
[10]  
Connors K. A., 1987, BINDING CONSTANTS, P339
123456