Development and function of B-1 cells - Commentary

被引：173

作者：

Hayakawa, K ^{[1
]}

Hardy, RR ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Inst Canc Res, Philadelphia, PA 19111 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(00)00098-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Results from immunoglobulin-transgenic mice and BCR-mutant mice have been widely interpreted in recent years as supporting a simple 'activation' model for the origin of CD5+/B-1 B cells. However cell transfer experiments over 10 years ago and recent work investigating pre-BCR signaling suggest striking differences between B cell development in fetal liver and adult bone marrow, lending support for a 'lineage' model that we favor. Recent progress has been made relating to the development and function of the CD5+/B-1 B cell subpopulation in mice; the data can be viewed in the context of the generation of this subpopulation by a distinctive fetal B cell developmental process.

引用

页码：346 / 353

页数：8

共 62 条

[1] Porcine CD5 gene and gene product identified on the basis of inter-species conserved cytoplasmic domain sequences [J].

Appleyard, GD ;

Wilkie, BN .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 60 (3-4) :275-283

[2]

Appleyard GD, 1998, CLIN EXP IMMUNOL, V111, P225

[3] CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity [J].

Azzam, HS ;

Grinberg, A ;

Lui, K ;

Shen, H ;

Shores, EW ;

Love, PE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2301-2311

[4] Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent [J].

Bao, S ;

Beagley, KW ;

Murray, AM ;

Caristo, V ;

Matthaei, KI ;

Young, IG ;

Husband, AJ .

IMMUNOLOGY, 1998, 94 (02) :181-188

[5]

Bauch A, 1998, EUR J IMMUNOL, V28, P2167, DOI 10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO

[6]

2-L

[7] Increased VH 11 and VH Q52 gene use by splenic B cells in old mice associated with oligoclonal expansions of CD5+B cells [J].

Ben-Yehuda, A ;

Szabo, P ;

LeMaoult, J ;

Manavalan, JS ;

Weksler, ME .

MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 103 (02) :111-121

[8]

Berland R, 1998, J IMMUNOL, V161, P277

[9] A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5 [J].

Bikah, G ;

Lynd, FM ;

Aruffo, AA ;

Ledbetter, JA ;

Bondada, S .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (08) :1185-1196

[10] A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection [J].

Boes, M ;

Prodeus, AP ;

Schmidt, T ;

Carroll, MC ;

Chen, JZ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2381-2386

← 1 2 3 4 5 6 7 →