Microbial transformation of isocoronarin D by Cunninghamella echinulata NRRL 1386

被引：5
作者：
Chokchaisiri, Ratchanaporn [1 ]
Chaichompoo, Waraluck [2 ,3 ]
Sukcharoen, Oratai [4 ]
Suksamrarn, Apichart [2 ,3 ]
Ganranoo, Lucksagoon [1 ]
机构：
[1] Univ Phayao, Sch Sci, Dept Chem, Muang 56000, Phayao, Thailand
[2] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok, Thailand
[3] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok, Thailand
[4] Ramkhamhang Univ, Fac Sci, Dept Biotechnol, Bangkok, Thailand
来源：
NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 20期
关键词：
Isocoronarin D; Curcuma comosa; Cunninghamella echinulata; microbial transformation; LABDANE DITERPENES; DRUG-METABOLISM; BIOTRANSFORMATION; BLAKESLEEANA; HYDROXYLATION; FUNGUS; ACID;
D O I：
10.1080/14786419.2018.1509331
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The diterpene isocoronarin D (1) is a bioactive major constituent of labdane diterpene from the aerial parts of Curcuma comosa Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of 1 was performed by the fungus Cunninghamella echinulata NRRL 1386 to yield three new metabolites, 3 beta-hydroxyisocoronarin D (2), 6 alpha-hydroxyisocoronarin D (3) and 3 beta,7 alpha-dihydroxyisocoronarin D (4). The structures of the new compounds were elucidated by spectroscopic techniques.
引用
收藏
页码：2890 / 2896
页数：7
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