Correlation of humoral immune responses to different SARS-CoV-2 antigens with virus neutralizing antibodies and symptomatic severity in a German COVID-19 cohort

被引：38

作者：

Rockstroh, Alexandra ^{[1
]}

Wolf, Johannes ^{[2
,3
]}

Fertey, Jasmin ^{[1
]}

Kalbitz, Sven ^{[4
]}

Schroth, Stefanie ^{[4
]}

Luebbert, Christoph ^{[4
,5
,6
]}

Ulbert, Sebastian ^{[1
]}

Borte, Stephan ^{[2
,3
]}

机构：

[1] Fraunhofer Inst Cell Therapy & Immunol, Leipzig, Germany

[2] Hosp St Georg, Dept Lab Med, Leipzig, Germany

[3] Hosp St Georg Leipzig, ImmunoDeficiencyCtr Leipzig IDCL, Jeffrey Modell Diagnost & Res Ctr Primary Immunod, Leipzig, Germany

[4] Hosp St Georg, Dept Infect Dis Trop Med Nephrol & Rheumatol, Leipzig, Germany

[5] Leipzig Univ Hosp, Interdisciplinary Ctr Infect Dis, Leipzig, Germany

[6] Leipzig Univ Hosp, Dept Med 2, Div Infect Dis & Trop Med, Leipzig, Germany

来源：

EMERGING MICROBES & INFECTIONS | 2021年 / 10卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

COVID-19; neutralizing antibodies; inactivated SARS-CoV-2; humoral immunity; RBD-ELISA; nucleocapsid-ELISA; S1-ELISA; SURVEILLANCE; IGM;

D O I：

10.1080/22221751.2021.1913973

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monitoring the humoral protective immune response and its durability after SARS-CoV-2 infections is essential for risk assessment of reinfections, the improvement of diagnostic methods and the evaluation of vaccine trials. We have analyzed neutralizing antibodies and IgG responses specific to different antigens, including the inactivated whole-virion of SARS-CoV-2, the spike subunit 1 protein and its receptor binding domain, as well as the nucleocapsid protein. We show the dynamic developments of the responses from the early convalescent stages up to 9 months post symptoms onset in follow-up samples from 57 COVID-19 patients with varying clinical severity. By correlating antibody signals to neutralizing titres, valid diagnostic markers for the estimation of neutralizing protection could be identified.

引用

页码：774 / 781

页数：8

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