Rewiring of hindlimb corticospinal neurons after spinal cord injury

被引：142

作者：

Ghosh, Arko ^{[1
,4
]}

Haiss, Florent ^{[2
]}

Sydekum, Esther ^{[1
,3
]}

Schneider, Regula ^{[1
,4
]}

Gullo, Miriam ^{[1
,4
]}

Wyss, Matthias T. ^{[2
]}

Mueggler, Thomas ^{[1
,3
]}

Baltes, Christof ^{[1
,3
]}

Rudin, Markus ^{[1
,2
,3
]}

Weber, Bruno ^{[2
]}

Schwab, Martin E. ^{[1
,4
]}

机构：

[1] Swiss Fed Inst Technol, Zurich, Switzerland

[2] Univ Zurich, Inst Pharmacol & Toxicol, Zurich, Switzerland

[3] Univ Zurich, Inst Biomed Engn, Zurich, Switzerland

[4] Univ Zurich, Brain Res Inst, Zurich, Switzerland

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

PRIMARY SOMATOSENSORY CORTEX; PYRAMIDAL TRACT CELLS; MOTOR CORTEX; ADULT-RATS; PLASTICITY; REGENERATION; CONNECTIONS; STIMULATION; ACTIVATION; RESPONSES;

D O I：

10.1038/nn.2448

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Little is known about the functional role of axotomized cortical neurons that survive spinal cord injury. Large thoracic spinal cord injuries in adult rats result in impairments of hindlimb function. Using retrograde tracers, we found that axotomized corticospinal axons from the hindlimb sensorimotor cortex sprouted in the cervical spinal cord. Mapping of these neurons revealed the emergence of a new forelimb corticospinal projection from the rostral part of the former hindlimb cortex. Voltage-sensitive dye (VSD) imaging and blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI) revealed a stable expansion of the forelimb sensory map, covering in particular the former hindlimb cortex containing the rewired neurons. Therefore, axotomised hindlimb corticospinal neurons can be incorporated into the sensorimotor circuits of the unaffected forelimb.

引用

页码：97 / U266

页数：10

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